diff --git a/Pipfile b/Pipfile
index 6169ceb8..562d6c3f 100644
--- a/Pipfile
+++ b/Pipfile
@@ -22,7 +22,7 @@ tabulate = "==0.9.0"
 cryptography = "==41.0.6"
 semver = "==3.0.1"
 httpx = {extras = ["http2"], version = "==0.24.1"}
-biopython = "==1.81"
+biopython = "==1.86"
 XlsxWriter = "==3.2.0"
 
 [requires]
diff --git a/Pipfile.lock b/Pipfile.lock
index b5ea5c06..60f9203b 100644
--- a/Pipfile.lock
+++ b/Pipfile.lock
@@ -1,7 +1,7 @@
 {
     "_meta": {
         "hash": {
-            "sha256": "7492e7849997908649cacd62091447f90afc53aa71d779137254f302b4b6019d"
+            "sha256": "ebc4f889c987b714cd31733666da3cf4753fa8c08af6dd822484111fa5695c50"
         },
         "pipfile-spec": 6,
         "requires": {
@@ -48,38 +48,57 @@
         },
         "biopython": {
             "hashes": [
-                "sha256:11d673698b3d0d6589292ea951fb62cb24ea27d273eca0d08dbbd956690f97f5",
-                "sha256:175fcddc9f22a070aa6db54755d60c4b31090cc39f5f5f4b0a9a5d1ae3b45cd7",
-                "sha256:22f5741aca91af0a76c0d5617e58e554fd3374bbd16e0c0ac1facf45b107313b",
-                "sha256:2cf38112b6d8415ad39d6a611988cd11fb5f33eb09346666a87263beba9614e0",
-                "sha256:2f9cfaf16d55ab80d514e7aebe5710dabe4e4ff47ede851031202e33b3249da3",
-                "sha256:35506e39822c52d11cf09a3951e82375ca1bb9303960b4286acf02c9a6f6c4cc",
-                "sha256:3b36ba1bf6395c09a365c53530c9d71f3617763fa2c1d452b3d8948368c0f1de",
-                "sha256:655df416936662c0c8a06a549cb25e1560e1fea5067d850f34fb714b8a3fae6c",
-                "sha256:65b93b513ce9dd7b2ce058720eadf42cd03f312db3409356efeb93123d1320aa",
-                "sha256:6ebfbce0d91796c7aef422ee9dffe8827e07e5abaa94545e006f1f20e965c80b",
-                "sha256:762c6c43a8486b5fcd07f136a3217b87d24755618b9ea9da1f17124ff44c2ad6",
-                "sha256:793c42a376cd63f62f8a088ce39b7dc6b5c55e4e9031d887c434de1595bfa4b8",
-                "sha256:7a168709694e10b338718c18d967edd5b56c237dc88642c22275796007a70000",
-                "sha256:7c5c07123ff5f44c9e6b5369df854a38afd3c0c50ef58498a0ae8f7eb799f3e8",
-                "sha256:811796f8d222aa3869a50e31e54ce62b69106b47cd8bb06934867c0d843297b5",
-                "sha256:8bb0c690c7368f255ed45236bf0f5464b476b8c083c8f634533921af78278261",
-                "sha256:919a2c583cabf9c96d2ae4e1245a6b0376932fb342aca302a0fc198b71ab3275",
-                "sha256:97cbdbed01b2512471f36c74b91658d1dfbdcbf39bc038f6ce5a41c3e60a8fc6",
-                "sha256:9ba33244f0eff830beaa7240065bdb5095d96fded6599b76bbb9ddab45cd2bbd",
-                "sha256:9ec149487f3d1e0cf2b52b6071641c161ed545b0855ff51a71506152e14fc5bb",
-                "sha256:a51d9c1d1b4b634447535da74a644fae59bc234fbbf9001e2dc6b6fbabb98019",
-                "sha256:b09efcb4733c8770f25eab5fe555a96a08f5ab9e1bc36939e08ebf2ffbf3e0f1",
-                "sha256:b37c0d24191e5c96ca02415a5188551980c83a0d518bbc4ffe3c9a5d1fe0ee81",
-                "sha256:ccd729249fd5f586dd4c2a3507c2ea2456825d7e615e97c07c409c850eaf4594",
-                "sha256:daeab15274bbcc0455cbd378636e14f53bc7c5b1f383e77021d7222e72cc3418",
-                "sha256:e41b55edcfd448630e77bf4de66a7235324a8a149621499891da6bd1d5085b9a",
-                "sha256:ee51bb1cd7decffd24da6b76d5e01b7e2fd818ab85cf0c180226cbb5793a3abd",
-                "sha256:ef7c79b65b0b3f3c7dc59e20a7f8ae5758d8e852cb8b9cace590dc5617e348ba"
+                "sha256:02aef2e31cc92544f574ff837cabaaaf53733f3a6b5a433f781c59e5424a7576",
+                "sha256:04f9abdf6cbf0087850de5f8148da0d420c4cb87905bf4de3145ad24a8d55dcd",
+                "sha256:0a95321ca929c04c934e62252c9e2cc5c4fd13ce575798d98af2d79512334b9b",
+                "sha256:137fe9aafd93baa5127d17534b473f6646f92a883f52b34f7c306b800ac50038",
+                "sha256:1859830b8262785c6b59dfe0c82cddb643974f63b9d2779bb9f3e2c47c0a95da",
+                "sha256:186e2065c0d1a6c2afc85b9c21a2911a931949668bd73b4c03f429a31b3589f8",
+                "sha256:187c3c24dd2255e7328f3e0523ab5d6350b73ff562517de0c1922385617101d2",
+                "sha256:192c61bc3d782c171b7d50bb7d8189d84790d6e3c4b24fd41d1d7ffc7d303efe",
+                "sha256:1d4dd9090caaf364a08ab54cd561f37c5f4ea5bcc8f0189d332dcd36d6df5767",
+                "sha256:236ca61aa996f12cbc65a8d6a15abfac70b9ee800656629b784c6a240e7d8dc0",
+                "sha256:2e62504faac6e62fe26e40d6905a69519d8b7b5b0506a426d641b218fde788b5",
+                "sha256:2f6b205dcb4101cefa5c615114bd35a19f656abb9d340eb3cf190f829e43800a",
+                "sha256:35a6b9c5dcdfb5c2631a313a007f3f41a7d72573ba2b68c962e10ea92096ff3b",
+                "sha256:4506ce7dbdf885cb24d1f5439362c3c07f1b6f90761a0d20fe16a2a9ea5702a5",
+                "sha256:4a6ab2c60742f1c8494cfbbe3b7a8b45f0400c8f2b36b686b895d5e4d625f04e",
+                "sha256:5329a777ba90ea624447173046e77c4df2862acc46eea4e94fe2211fe041750f",
+                "sha256:593ec6a2a4fedec08ddcee1a8a0e0b0ed56835b2714904b352ec4a93d5b9d973",
+                "sha256:5aa8c9e92ee6fe59dfe0d2c2daf9a9eec6b812c78328caad038f79163c500218",
+                "sha256:6915a09859159598b9421e7240561692e7bb4084e5340c4dbb2435c5c38805a2",
+                "sha256:6ac858fd71f1093380d8b0a16acf060e7c228ad65f9ecacdb9f5760cfb9f59b1",
+                "sha256:6cceb32b9036bbdc59962e31bd1605ece24edc226c0d50f99839948b5b5c9dda",
+                "sha256:6fbbfe19e12170754adb9632155b7e3be0d4c247f0a2e09d3917bec859282de1",
+                "sha256:8d4530060aadc6af060a9a049da91a582738837e187fcea80486c71eca74ae59",
+                "sha256:8e1b12819a78242b529f54e5d2d00ad90023710a5846ca0f2011ac989fd17d4b",
+                "sha256:90591f4554c09d311193e7774b5143442c67e178a5b7d929aaa2a054048b22a7",
+                "sha256:93a50b586a4d2cec68ab2f99d03ef583c5761d8fba5535cb8e81da781d0d92ff",
+                "sha256:ba88b0754ad53c93eba11d910364cfc773686933c89a886522309ba903151e50",
+                "sha256:baf19d9237aaaa387a68f8f055f978af5c80338d7e037ab028e8d768928f1250",
+                "sha256:bb86e4383c02fdb2571a38947153346e6f5cd38e22de1df40f54d2a3c51d02a8",
+                "sha256:be3d83152fe3232e2d197896a506902b84ad60d40b3f1d1fc934914d138c6dc1",
+                "sha256:caa70c1639b3306549605f9273753bdbf8cd6d6d352cecf23afbda3c911694f3",
+                "sha256:d077f01d1f69f77a26cac46163d4ea45eb4e6509a68feb7f15e665b7e1de0a99",
+                "sha256:d53a78bf960397826219f08f87b061ad7f227527d19986e830eeab60d370b597",
+                "sha256:da4bcf5a48ee647624e2d0bedac7fb1c24ef0facd514519cca074593b8a6a40e",
+                "sha256:dcd94717e83ba891ebd9acaecbf05ad38313095ca5706caf6c38fa3f2aa17528",
+                "sha256:dd2f9ebf9b14d67ca92f48779c4f0ba404c35dba3e8b9d6c34d1a3591c3b746d",
+                "sha256:dfd906c47b6fb38e3abb9f52e0c06822e6e82a043d38c2000773692c29db1ed8",
+                "sha256:e161f3d3b6e65fbfd1ce22a01c3e9fa9da789adde4972fd0cc2370795ea5357b",
+                "sha256:e784dc8382430c9893aa084ca18fe8a8815b5811f1c324492ef3f4b54e664fff",
+                "sha256:efbb9bc4415a1e2c1c986ba261b02857bc0c9eed098b15493f1cc5c4a1e02409",
+                "sha256:efeee7c37f2331d2c55704df39e122189cc237ffd7511f34158418ad728131b8",
+                "sha256:f0f040ff85bd7d0ee06574bc6d032bc666802f2fe781b0c316b936237eb3d17e",
+                "sha256:f6f2f1dc75423b15d8a22b8eceae32785736612b6740688526401b8c2d821270",
+                "sha256:f8d372aae21d79b11613751c6ae23c88db0e94d25b7567b1f67aa0304fb61667",
+                "sha256:f96b7441f456c7eecad5c6e61e75b0db1435c489be7cc5e4f97dd4e60921747c",
+                "sha256:fb3a11a98e49428720dca227e2a5bdd57c973ee7c4df3cf6734c0aa13fd134c7",
+                "sha256:ffeba620c4786ea836efee235a9c6333b94e922b89de1449a4782dcc15246ff1"
             ],
             "index": "pypi",
-            "markers": "python_version >= '3.7'",
-            "version": "==1.81"
+            "markers": "python_version >= '3.10'",
+            "version": "==1.86"
         },
         "certifi": {
             "hashes": [
@@ -375,45 +394,83 @@
         },
         "numpy": {
             "hashes": [
-                "sha256:03a8c78d01d9781b28a6989f6fa1bb2c4f2d51201cf99d3dd875df6fbd96b23b",
-                "sha256:08beddf13648eb95f8d867350f6a018a4be2e5ad54c8d8caed89ebca558b2818",
-                "sha256:1af303d6b2210eb850fcf03064d364652b7120803a0b872f5211f5234b399f20",
-                "sha256:1dda2e7b4ec9dd512f84935c5f126c8bd8b9f2fc001e9f54af255e8c5f16b0e0",
-                "sha256:2a02aba9ed12e4ac4eb3ea9421c420301a0c6460d9830d74a9df87efa4912010",
-                "sha256:2e4ee3380d6de9c9ec04745830fd9e2eccb3e6cf790d39d7b98ffd19b0dd754a",
-                "sha256:3373d5d70a5fe74a2c1bb6d2cfd9609ecf686d47a2d7b1d37a8f3b6bf6003aea",
-                "sha256:47711010ad8555514b434df65f7d7b076bb8261df1ca9bb78f53d3b2db02e95c",
-                "sha256:4c66707fabe114439db9068ee468c26bbdf909cac0fb58686a42a24de1760c71",
-                "sha256:50193e430acfc1346175fcbdaa28ffec49947a06918b7b92130744e81e640110",
-                "sha256:52b8b60467cd7dd1e9ed082188b4e6bb35aa5cdd01777621a1658910745b90be",
-                "sha256:60dedbb91afcbfdc9bc0b1f3f402804070deed7392c23eb7a7f07fa857868e8a",
-                "sha256:62b8e4b1e28009ef2846b4c7852046736bab361f7aeadeb6a5b89ebec3c7055a",
-                "sha256:666dbfb6ec68962c033a450943ded891bed2d54e6755e35e5835d63f4f6931d5",
-                "sha256:675d61ffbfa78604709862923189bad94014bef562cc35cf61d3a07bba02a7ed",
-                "sha256:679b0076f67ecc0138fd2ede3a8fd196dddc2ad3254069bcb9faf9a79b1cebcd",
-                "sha256:7349ab0fa0c429c82442a27a9673fc802ffdb7c7775fad780226cb234965e53c",
-                "sha256:7ab55401287bfec946ced39700c053796e7cc0e3acbef09993a9ad2adba6ca6e",
-                "sha256:7e50d0a0cc3189f9cb0aeb3a6a6af18c16f59f004b866cd2be1c14b36134a4a0",
-                "sha256:95a7476c59002f2f6c590b9b7b998306fba6a5aa646b1e22ddfeaf8f78c3a29c",
-                "sha256:96ff0b2ad353d8f990b63294c8986f1ec3cb19d749234014f4e7eb0112ceba5a",
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-                "sha256:ab47dbe5cc8210f55aa58e4805fe224dac469cde56b9f731a4c098b91917159a",
-                "sha256:afedb719a9dcfc7eaf2287b839d8198e06dcd4cb5d276a3df279231138e83d30",
-                "sha256:b3ce300f3644fb06443ee2222c2201dd3a89ea6040541412b8fa189341847218",
-                "sha256:b97fe8060236edf3662adfc2c633f56a08ae30560c56310562cb4f95500022d5",
-                "sha256:bfe25acf8b437eb2a8b2d49d443800a5f18508cd811fea3181723922a8a82b07",
-                "sha256:cd25bcecc4974d09257ffcd1f098ee778f7834c3ad767fe5db785be9a4aa9cb2",
-                "sha256:d209d8969599b27ad20994c8e41936ee0964e6da07478d6c35016bc386b66ad4",
-                "sha256:d5241e0a80d808d70546c697135da2c613f30e28251ff8307eb72ba696945764",
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-                "sha256:f870204a840a60da0b12273ef34f7051e98c3b5961b61b0c2c1be6dfd64fbcd3",
-                "sha256:ffa75af20b44f8dba823498024771d5ac50620e6915abac414251bd971b4529f"
-            ],
-            "markers": "python_version >= '3.9'",
-            "version": "==1.26.4"
+                "sha256:00dc4e846108a382c5869e77c6ed514394bdeb3403461d25a829711041217d5b",
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+                "sha256:5ee6609ac3604fa7780e30a03e5e241a7956f8e2fcfe547d51e3afa5247ac47f",
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+                "sha256:aa5bc7c5d59d831d9773d1170acac7893ce3a5e130540605770ade83280e7188",
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