diff --git a/profile/README.md b/profile/README.md
index 4ee8525..5bd6712 100644
--- a/profile/README.md
+++ b/profile/README.md
@@ -132,27 +132,26 @@ CCBR offers end-to-end analysis pipelines for NGS data analysis.
Here is a list of our prominent pipelines and their release schedule on
BIOWULF:
-| Data Type | Pipeline Name | CLI\* available since |
-| ----------------------- | ---------------------------------------------------------------------------------------------------------------------------------------- | -------------------------------- |
-| RNASeq1 | [RENEE](https://github.com/CCBR/RENEE) | July 3rd 2023 |
-| WESSeq2 | [XAVIER](https://github.com/CCBR/XAVIER) | July 21st 2023 |
-| ATACSeq3 | [ASPEN](https://github.com/CCBR/ASPEN) | November 30th 2023 |
-| ChIPSeq4 | [CHAMPAGNE](https://github.com/CCBR/CHAMPAGNE) | October 15th 2023 |
-| CRISPRSeq5 | [CRISPIN](https://github.com/CCBR/CRISPIN) | September 2023 |
-| CUT&RunSeq6 | [CARLISLE](https://github.com/CCBR/CARLISLE) | October 31st 2023 |
-| EV-Seq10 | [ESCAPE](https://github.com/CCBR/ESCAPE) | March 26th 2024 |
-| circRNASeq7 | [CHARLIE](https://github.com/CCBR/CHARLIE) | September 16th 2024 |
-| scRNASeq8 | [SINCLAIR](https://github.com/CCBR/SINCLAIR) | February 28th 2025 |
-| WGSSeq9 | [LOGAN](https://github.com/CCBR/LOGAN) | May 31st 2025 |
-| spatialSeq11 | [SPENCER](https://github.com/CCBR/SPENCER) | TBD |
+| Data Type | Pipeline Name | Description | CLI\* available since |
+| ----------------------- | ---------------------------------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ | -------------------------------- |
+| RNASeq1 | [RENEE](https://github.com/CCBR/RENEE) | Comprehensive RNA-seq workflow that combines contamination screening, adapter trimming, two-pass STAR alignment, and RSEM quantification. It generates gene and isoform count matrices, fusion calls, and MultiQC-style quality summaries for cohort-level review. | July 3rd 2023 |
+| WESSeq2 | [XAVIER](https://github.com/CCBR/XAVIER) | Whole-exome sequencing pipeline aligned to Broad-style best practices using a reproducible Snakemake execution model. It accepts FASTQ or BAM inputs and supports germline and somatic variant calling, CNV inference, and downstream annotation. | July 21st 2023 |
+| ATACSeq3 | [ASPEN](https://github.com/CCBR/ASPEN) | ATAC-seq analysis workflow for preliminary QC, peak calling, and differential chromatin accessibility testing. It is configured for Biowulf usage and provides standardized outputs for regulatory genomics interpretation. | November 30th 2023 |
+| ChIPSeq4 | [CHAMPAGNE](https://github.com/CCBR/CHAMPAGNE) | ChIP-seq analysis pipeline with support for configurable reference genomes and optional spike-in genome handling. It produces reproducible peak-centric outputs from aligned sequencing data and can be run through CCBR module-based workflows. | October 15th 2023 |
+| CRISPRSeq5 | [CRISPIN](https://github.com/CCBR/CRISPIN) | CRISPR screen sequencing workflow designed for reproducible run setup and execution on Biowulf. It processes screening libraries into analysis-ready outputs suitable for guide-level and gene-level interpretation. | September 2023 |
+| CUT&RunSeq6 | [CARLISLE](https://github.com/CCBR/CARLISLE) | CUT&RUN pipeline that performs peak calling with MACS2, SEACR, and GoPeaks using spike-in-normalized FASTQ inputs. It is built in Snakemake and tuned for reproducible chromatin profiling on Biowulf. | October 31st 2023 |
+| EV-Seq10 | [ESCAPE](https://github.com/CCBR/ESCAPE) | Extracellular vesicle RNA-seq workflow for EV-derived libraries from raw reads through analysis-ready quantification outputs. It emphasizes consistent QC and standardized processing for comparative EV transcriptomics. | March 26th 2024 |
+| circRNASeq7 | [CHARLIE](https://github.com/CCBR/CHARLIE) | circRNA pipeline for detection, annotation, and quantification of host and viral circular RNAs. It orchestrates multiple circRNA callers in parallel, including CIRCExplorer2 and CIRI2-based paths, to support robust cross-method discovery. | September 16th 2024 |
+| scRNASeq8 | [SINCLAIR](https://github.com/CCBR/SINCLAIR) | Single-cell analysis resource supporting multiple next-generation modalities in a reproducible Nextflow framework. It starts from FASTQ or h5-aligned inputs, performs per-sample QC, and generates per-contrast integration reports. | February 28th 2025 |
+| WGSSeq9 | [LOGAN](https://github.com/CCBR/LOGAN) | Whole-genome sequencing pipeline based on Broad-aligned processing patterns and Nextflow orchestration. It calls and annotates germline and somatic variants, CNVs, and SVs with reproducible containerized execution. | May 31st 2025 |
+| spatialSeq11 | [SPENCER](https://github.com/CCBR/SPENCER) | Spatial sequencing workflow for processing location-aware transcriptomic measurements across tissue regions. It is designed to produce structured outputs for downstream spatial feature analysis, integration, and visualization. | TBD |
\* CLI = Command Line Interface
> ℹ️ GUI (Graphical User Interface) development has been suspended for
> the time being but may resume in the future.
- **1** RENEE=_Rna sEquencing aNalysis pipElinE_. Starts with raw
-fastq files and ends with a counts matrix.
+ **1** RENEE=_Rna sEquencing aNalysis pipElinE_.
**2** XAVIER=_eXome Analysis and Variant explorER_.
@@ -161,14 +160,11 @@ fastq files and ends with a counts matrix.
**4** CHAMPAGNE=_CHromAtin iMmuno PrecipitAtion sequencinG
aNalysis pipEline_.
- **5** CRISPIN=_CRISPr screen sequencing analysis pipelINe_.
-CRISPRSeq analysis with MAGeCK, drugZ and BAGEL2.
+ **5** CRISPIN=_CRISPr screen sequencing analysis pipelINe_.
- **6** CARLISLE=_Cut And Run anaLysIS pipeLinE_. Supports human and
-mouse samples with (recommended) or without spike-ins.
+ **6** CARLISLE=_Cut And Run anaLysIS pipeLinE_.
- **7** CHARLIE=_Circrnas in Host And viRuses anaLysis pIpEline_.
-Finds known and novel circRNAs in human/mouse + virus genomes.
+ **7** CHARLIE=_Circrnas in Host And viRuses anaLysis pIpEline_.
**8** SINCLAIR=_SINgle CelL AnalysIs Resource_.
diff --git a/profile/README.qmd b/profile/README.qmd
index 3fc02da..aa2e359 100644
--- a/profile/README.qmd
+++ b/profile/README.qmd
@@ -89,25 +89,25 @@ CCBR offers end-to-end analysis pipelines for NGS data analysis.
Here is a list of our prominent pipelines and their release schedule on BIOWULF:
-| Data Type | Pipeline Name | CLI\* available since |
-| ----------------------- | ---------------------------------------------------------------------------------------------------------------------------------------- | --------------------------------- |
-| RNASeq1 | [RENEE](https://github.com/CCBR/RENEE) | July 3rd 2023 |
-| WESSeq2 | [XAVIER](https://github.com/CCBR/XAVIER) | July 21st 2023 |
-| ATACSeq3 | [ASPEN](https://github.com/CCBR/ASPEN) | November 30th 2023 |
-| ChIPSeq4 | [CHAMPAGNE](https://github.com/CCBR/CHAMPAGNE) | October 15th 2023 |
-| CRISPRSeq5 | [CRISPIN](https://github.com/CCBR/CRISPIN) | September 2023 |
-| CUT&RunSeq6 | [CARLISLE](https://github.com/CCBR/CARLISLE) | October 31st 2023 |
-| EV-Seq10 | [ESCAPE](https://github.com/CCBR/ESCAPE) | March 26th 2024 |
-| circRNASeq7 | [CHARLIE](https://github.com/CCBR/CHARLIE) | September 16th 2024 |
-| scRNASeq8 | [SINCLAIR](https://github.com/CCBR/SINCLAIR) | February 28th 2025 |
-| WGSSeq9 | [LOGAN](https://github.com/CCBR/LOGAN) | May 31st 2025 |
-| spatialSeq11 | [SPENCER](https://github.com/CCBR/SPENCER) | TBD |
+| Data Type | Pipeline Name | Description | CLI\* available since |
+| ----------------------- | ---------------------------------------------------------------------------------------------------------------------------------------- | ----------- | --------------------------------- |
+| RNASeq1 | [RENEE](https://github.com/CCBR/RENEE) | Comprehensive RNA-seq workflow that combines contamination screening, adapter trimming, two-pass STAR alignment, and RSEM quantification. It generates gene and isoform count matrices, fusion calls, and MultiQC-style quality summaries for cohort-level review. | July 3rd 2023 |
+| WESSeq2 | [XAVIER](https://github.com/CCBR/XAVIER) | Whole-exome sequencing pipeline aligned to Broad-style best practices using a reproducible Snakemake execution model. It accepts FASTQ or BAM inputs and supports germline and somatic variant calling, CNV inference, and downstream annotation. | July 21st 2023 |
+| ATACSeq3 | [ASPEN](https://github.com/CCBR/ASPEN) | ATAC-seq analysis workflow for preliminary QC, peak calling, and differential chromatin accessibility testing. It is configured for Biowulf usage and provides standardized outputs for regulatory genomics interpretation. | November 30th 2023 |
+| ChIPSeq4 | [CHAMPAGNE](https://github.com/CCBR/CHAMPAGNE) | ChIP-seq analysis pipeline with support for configurable reference genomes and optional spike-in genome handling. It produces reproducible peak-centric outputs from aligned sequencing data and can be run through CCBR module-based workflows. | October 15th 2023 |
+| CRISPRSeq5 | [CRISPIN](https://github.com/CCBR/CRISPIN) | CRISPR screen sequencing workflow designed for reproducible run setup and execution on Biowulf. It processes screening libraries into analysis-ready outputs suitable for guide-level and gene-level interpretation. | September 2023 |
+| CUT&RunSeq6 | [CARLISLE](https://github.com/CCBR/CARLISLE) | CUT&RUN pipeline that performs peak calling with MACS2, SEACR, and GoPeaks using spike-in-normalized FASTQ inputs. It is built in Snakemake and tuned for reproducible chromatin profiling on Biowulf. | October 31st 2023 |
+| EV-Seq10 | [ESCAPE](https://github.com/CCBR/ESCAPE) | Extracellular vesicle RNA-seq workflow for EV-derived libraries from raw reads through analysis-ready quantification outputs. It emphasizes consistent QC and standardized processing for comparative EV transcriptomics. | March 26th 2024 |
+| circRNASeq7 | [CHARLIE](https://github.com/CCBR/CHARLIE) | circRNA pipeline for detection, annotation, and quantification of host and viral circular RNAs. It orchestrates multiple circRNA callers in parallel, including CIRCExplorer2 and CIRI2-based paths, to support robust cross-method discovery. | September 16th 2024 |
+| scRNASeq8 | [SINCLAIR](https://github.com/CCBR/SINCLAIR) | Single-cell analysis resource supporting multiple next-generation modalities in a reproducible Nextflow framework. It starts from FASTQ or h5-aligned inputs, performs per-sample QC, and generates per-contrast integration reports. | February 28th 2025 |
+| WGSSeq9 | [LOGAN](https://github.com/CCBR/LOGAN) | Whole-genome sequencing pipeline based on Broad-aligned processing patterns and Nextflow orchestration. It calls and annotates germline and somatic variants, CNVs, and SVs with reproducible containerized execution. | May 31st 2025 |
+| spatialSeq11 | [SPENCER](https://github.com/CCBR/SPENCER) | Spatial sequencing workflow for processing location-aware transcriptomic measurements across tissue regions. It is designed to produce structured outputs for downstream spatial feature analysis, integration, and visualization. | TBD |
\* CLI = Command Line Interface
> ℹ️ GUI (Graphical User Interface) development has been suspended for the time being but may resume in the future.
- **1** RENEE=_Rna sEquencing aNalysis pipElinE_. Starts with raw fastq files and ends with a counts matrix.
+ **1** RENEE=_Rna sEquencing aNalysis pipElinE_.
**2** XAVIER=_eXome Analysis and Variant explorER_.
@@ -115,11 +115,11 @@ Here is a list of our prominent pipelines and their release schedule on BIOWULF:
**4** CHAMPAGNE=_CHromAtin iMmuno PrecipitAtion sequencinG aNalysis pipEline_.
- **5** CRISPIN=_CRISPr screen sequencing analysis pipelINe_. CRISPRSeq analysis with MAGeCK, drugZ and BAGEL2.
+ **5** CRISPIN=_CRISPr screen sequencing analysis pipelINe_.
- **6** CARLISLE=_Cut And Run anaLysIS pipeLinE_. Supports human and mouse samples with (recommended) or without spike-ins.
+ **6** CARLISLE=_Cut And Run anaLysIS pipeLinE_.
- **7** CHARLIE=_Circrnas in Host And viRuses anaLysis pIpEline_. Finds known and novel circRNAs in human/mouse + virus genomes.
+ **7** CHARLIE=_Circrnas in Host And viRuses anaLysis pIpEline_.
**8** SINCLAIR=_SINgle CelL AnalysIs Resource_.