diff --git a/tests/debugger/test_debugger_exception_replay.py b/tests/debugger/test_debugger_exception_replay.py
index 52021532a3b..c77eee68bdf 100644
--- a/tests/debugger/test_debugger_exception_replay.py
+++ b/tests/debugger/test_debugger_exception_replay.py
@@ -374,7 +374,11 @@ def __scrub(
                 keys_to_remove = []
                 span_meta = get_span_meta(span, span_format)
                 for meta_key, meta_value in span_meta.items():
-                    if meta_key in {
+                    if meta_key.startswith("_dd.appsec.s."):
+                        # API Security samples schemas per (route, method, status) on a time window, so
+                        # which request of the test carries them is not deterministic
+                        keys_to_remove.append(meta_key)
+                    elif meta_key in {
                         "_dd.appsec.fp.http.endpoint",
                         "_dd.appsec.fp.http.header",
                         "_dd.appsec.fp.http.network",