diff --git a/requirements.txt b/requirements.txt
index 7e2f8c6..b89e818 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -11,5 +11,5 @@ scanpy==1.9.6
 scikit_learn==1.3.1
 scipy>=1.10
 seaborn>=0.12
-setuptools==56.0.0
+setuptools==65.5.1
 statsmodels==0.14.0