diff --git a/changelog.d/10621-asyncresource-heritage-shapes.md b/changelog.d/10621-asyncresource-heritage-shapes.md
new file mode 100644
index 0000000000..f103e3aa88
--- /dev/null
+++ b/changelog.d/10621-asyncresource-heritage-shapes.md
@@ -0,0 +1,24 @@
+### Fixed
+
+- **`class X extends AsyncResource` threw at `super()` unless the heritage
+  was a bare `import { AsyncResource } from "node:async_hooks"` binding**
+  (#10453). A local alias (`const Alias = AsyncResource`), a namespace
+  member (`ah.AsyncResource`), and a CJS destructured
+  `require('node:async_hooks')` — the exact shape `undici`'s API handlers
+  use everywhere (`lib/api/api-request.js` etc.) — all threw `Class
+  constructor AsyncResource cannot be invoked without 'new'`. Only the bare
+  import shape was recognized statically at HIR-lowering time
+  (`canonical_native_parent_name`, `crates/perry-hir/src/lower_decl/class_decl.rs`),
+  routing to the dedicated `js_async_resource_subclass_init` codegen; every
+  other shape fell through `js_fetch_or_value_super`
+  (`crates/perry-runtime/src/object/global_this/fetch_globals.rs`) to a
+  plain CALL of the bound `async_hooks` export, which throws by design
+  without `new`. `js_fetch_or_value_super` already resolves ANY heritage
+  value to its bound native module/method via
+  `bound_native_callable_module_and_method` for the WASI case, regardless
+  of how the value was reached — this fix adds the same recognition for
+  `async_hooks`'s `AsyncResource`, so every aliasing shape now runs the
+  same native-backing init the canonical import already used.
+  `AsyncLocalStorage` likely has the same gap but isn't fixed here — its
+  subclass-init helper lives in `perry-stdlib`, which `perry-runtime`
+  cannot depend on.
diff --git a/crates/perry-runtime/src/object/global_this/fetch_globals.rs b/crates/perry-runtime/src/object/global_this/fetch_globals.rs
index 2230073e09..2160572c59 100644
--- a/crates/perry-runtime/src/object/global_this/fetch_globals.rs
+++ b/crates/perry-runtime/src/object/global_this/fetch_globals.rs
@@ -655,7 +655,13 @@ pub unsafe extern "C" fn js_fetch_or_value_super(
             b"Super constructor null is not a constructor",
         );
     }
-    let wasi_parent = super::super::native_module::bound_native_callable_module_and_method(
+    // Resolve the parent to a bound native-module export VALUE, independent
+    // of how the heritage expression reached it: a bare import, a local
+    // alias, a namespace member, and a CJS destructured `require()` all
+    // produce the identical bound-closure representation (see
+    // `bound_native_callable_module_and_method`), even though only the bare
+    // import shape is recognized statically at HIR-lowering time.
+    let bound_native_parent = super::super::native_module::bound_native_callable_module_and_method(
         parent_val,
     )
     .or_else(|| {
@@ -665,10 +671,13 @@ pub unsafe extern "C" fn js_fetch_or_value_super(
             crate::object::class_registry::js_get_dynamic_parent_value(cid),
         )
     });
-    if wasi_parent.is_some_and(|(module, method)| {
-        super::super::native_module::normalize_native_module_alias(&module) == "wasi"
-            && method == "WASI"
-    }) {
+    if bound_native_parent
+        .as_ref()
+        .is_some_and(|(module, method)| {
+            super::super::native_module::normalize_native_module_alias(module.as_str()) == "wasi"
+                && method.as_str() == "WASI"
+        })
+    {
         let arg0 = if args_len >= 1 && !args_ptr.is_null() {
             *args_ptr
         } else {
@@ -677,6 +686,44 @@ pub unsafe extern "C" fn js_fetch_or_value_super(
         crate::wasi::js_wasi_init_subclass(this_box, arg0);
         return undef;
     }
+    // #10453: `class X extends AsyncResource` threw "Class constructor
+    // AsyncResource cannot be invoked without 'new'" for every heritage
+    // shape EXCEPT a bare `import { AsyncResource } from "node:async_hooks"`
+    // — the only shape `canonical_native_parent_name` recognizes statically
+    // (`crates/perry-hir/src/lower_decl/class_decl.rs`), which routes to the
+    // dedicated `js_async_resource_subclass_init` codegen
+    // (`crates/perry-codegen/src/expr/this_super_call.rs`). A local alias
+    // (`const Alias = AsyncResource`), a namespace member
+    // (`ah.AsyncResource`), and a CJS destructured
+    // `require('node:async_hooks')` all resolve `parent_val` to the exact
+    // same bound-native-export value the canonical import does, but HIR
+    // lowering can't see that statically for those shapes, so `super()` fell
+    // through to the ordinary value-super dispatch below — a plain CALL of
+    // the bound export, which `AsyncResource` throws on by design when
+    // invoked without `new` (`nm_dispatch_async_hooks`). Recognize the value
+    // here instead, exactly as the WASI arm above does, and run the same
+    // native-backing init the canonical path uses.
+    if bound_native_parent
+        .as_ref()
+        .is_some_and(|(module, method)| {
+            super::super::native_module::normalize_native_module_alias(module.as_str())
+                == "async_hooks"
+                && method.as_str() == "AsyncResource"
+        })
+    {
+        let type_value = if args_len >= 1 && !args_ptr.is_null() {
+            *args_ptr
+        } else {
+            undef
+        };
+        let options = if args_len >= 2 && !args_ptr.is_null() {
+            *args_ptr.add(1)
+        } else {
+            undef
+        };
+        crate::async_hooks::js_async_resource_subclass_init(this_box, type_value, options);
+        return undef;
+    }
     // `class X extends Temporal.<Type>` (non-spread `super(a, b)`): a Temporal
     // constructor returns a fresh NaN-boxed cell and does NOT mutate the
     // implicit `this`, so the ordinary dispatch below would drop that cell and
diff --git a/test-files/gap_10453_asyncresource_heritage_helper.cjs b/test-files/gap_10453_asyncresource_heritage_helper.cjs
new file mode 100644
index 0000000000..1e28c49d7d
--- /dev/null
+++ b/test-files/gap_10453_asyncresource_heritage_helper.cjs
@@ -0,0 +1,31 @@
+'use strict';
+// CommonJS half of test_gap_10453_asyncresource_heritage.ts: the exact shape
+// undici's API handlers use (`lib/api/api-request.js` etc.).
+const { AsyncResource } = require('node:async_hooks');
+const asyncHooks = require('node:async_hooks');
+
+class Plain extends AsyncResource {
+  constructor(type) {
+    super(type);
+  }
+}
+
+class InTry extends AsyncResource {
+  constructor(type) {
+    try {
+      super(type);
+    } catch (err) {
+      throw err;
+    }
+  }
+}
+
+// `require('node:async_hooks').AsyncResource` reached via a namespace member
+// on a plain `require()` result (not destructured).
+class ViaMemberExport extends asyncHooks.AsyncResource {
+  constructor(type) {
+    super(type);
+  }
+}
+
+module.exports = { Plain, InTry, ViaMemberExport };
diff --git a/test-files/test_gap_10453_asyncresource_heritage.ts b/test-files/test_gap_10453_asyncresource_heritage.ts
new file mode 100644
index 0000000000..02904833d8
--- /dev/null
+++ b/test-files/test_gap_10453_asyncresource_heritage.ts
@@ -0,0 +1,56 @@
+// #10453: `class X extends AsyncResource` threw "Class constructor
+// AsyncResource cannot be invoked without 'new'" at `super()` for every
+// heritage shape EXCEPT a bare `import { AsyncResource } from
+// "node:async_hooks"` binding. A local alias (`const Alias = AsyncResource`),
+// a namespace member (`ah.AsyncResource`), and a CJS destructured
+// `require('node:async_hooks')` all reach the same bound native export
+// VALUE the bare import does, but HIR lowering only recognized the bare
+// import shape statically, so `super()` for the other shapes fell through to
+// a plain CALL of the native export — and `AsyncResource` throws by design
+// when invoked without `new`.
+//
+// `undici` (`lib/api/api-request.js` etc.) uses exactly the CJS destructured
+// shape: `const { AsyncResource } = require('node:async_hooks'); class …
+// extends AsyncResource`.
+import { AsyncResource } from "node:async_hooks";
+import * as ah from "node:async_hooks";
+import { Plain, InTry, ViaMemberExport } from "./gap_10453_asyncresource_heritage_helper.cjs";
+
+const Alias = AsyncResource;
+
+class ViaImport extends AsyncResource {
+  constructor() {
+    super("X");
+  }
+}
+class ViaAlias extends Alias {
+  constructor() {
+    super("X");
+  }
+}
+class ViaNamespace extends ah.AsyncResource {
+  constructor() {
+    super("X");
+  }
+}
+function t(name: string, C: any, ...args: unknown[]) {
+  try {
+    const r = new C(...args);
+    console.log(
+      name,
+      "ok",
+      typeof r.runInAsyncScope,
+      typeof r.triggerAsyncId(),
+      r instanceof AsyncResource,
+    );
+  } catch (e: any) {
+    console.log(name, "threw:", e.message);
+  }
+}
+
+t("TS  extends AsyncResource (import)  ", ViaImport, "X");
+t("TS  extends Alias                   ", ViaAlias, "X");
+t("TS  extends ah.AsyncResource        ", ViaNamespace, "X");
+t("CJS destructured require, super()   ", Plain, "X");
+t("CJS destructured require, try{super}", InTry, "X");
+t("CJS namespace member export         ", ViaMemberExport, "X");