diff --git a/README.md b/README.md
index 73c00b6a..d8167aca 100644
--- a/README.md
+++ b/README.md
@@ -180,7 +180,9 @@ The configuration file defines:
 - The endpoints used to upload the anonymised DICOM data and the public and radiology
   [parquet files](./docs/file_types/parquet_files.md). We currently support the following endpoints:
     - `"none"`: no upload
-    - `"ftps"`: a secure FTP server (for both _DICOM_ and _parquet_ files)
+    - `"ftps"`: a secure FTP server using implicit TLS (for both _DICOM_ and _parquet_ files), e.g. UCL DSH
+    - `"ftpes"`: a secure FTP server using explicit TLS (for both _DICOM_ and _parquet_ files)
+
     - `"dicomweb"`: a DICOMweb server (for _DICOM_ files only).
       Requires the `DICOMWEB_*` environment variables to be set in `.env`
     - `"xnat"`: an [XNAT](https://www.xnat.org/) instance (for _DICOM_ files only)
diff --git a/pixl_core/src/core/project_config/pixl_config_model.py b/pixl_core/src/core/project_config/pixl_config_model.py
index f52c3584..c4b31d77 100644
--- a/pixl_core/src/core/project_config/pixl_config_model.py
+++ b/pixl_core/src/core/project_config/pixl_config_model.py
@@ -146,6 +146,7 @@ class _DestinationEnum(enum.StrEnum):
 
     none = "none"
     ftps = "ftps"
+    ftpes = "ftpes"
     dicomweb = "dicomweb"
     xnat = "xnat"
     tre = "tre"
diff --git a/pixl_core/src/core/uploader/__init__.py b/pixl_core/src/core/uploader/__init__.py
index b244ebdc..b5fc58ad 100644
--- a/pixl_core/src/core/uploader/__init__.py
+++ b/pixl_core/src/core/uploader/__init__.py
@@ -28,7 +28,7 @@
 from core.project_config import load_project_config
 
 from ._dicomweb import DicomWebUploader
-from ._ftps import FTPSUploader
+from ._ftps import FTPESUploader, FTPSUploader
 from ._treapi import TreApiUploader
 from ._xnat import XNATUploader
 
@@ -41,6 +41,7 @@ def get_uploader(project_slug: str) -> Uploader:
     """Uploader Factory, returns uploader instance based on destination."""
     choices: dict[str, type[Uploader]] = {
         "ftps": FTPSUploader,
+        "ftpes": FTPESUploader,
         "dicomweb": DicomWebUploader,
         "xnat": XNATUploader,
         "tre": TreApiUploader,
diff --git a/pixl_core/src/core/uploader/_ftps.py b/pixl_core/src/core/uploader/_ftps.py
index 1fa91b7e..652772db 100644
--- a/pixl_core/src/core/uploader/_ftps.py
+++ b/pixl_core/src/core/uploader/_ftps.py
@@ -38,6 +38,7 @@
 class ImplicitFtpTls(ftplib.FTP_TLS):
     """
     FTP_TLS subclass that automatically wraps sockets in SSL to support implicit FTPS.
+    Use explicit TLS where possible.
 
     https://stackoverflow.com/questions/12164470/python-ftp-implicit-tls-connection-issue
     """
@@ -63,6 +64,8 @@ def sock(self, value: socket | None) -> None:
 class FTPSUploader(Uploader):
     """Upload strategy for an FTPS server."""
 
+    ftp_tls_class: type[ftplib.FTP_TLS] = ImplicitFtpTls
+
     def __init__(self, project_slug: str, keyvault_alias: str | None) -> None:
         """Create instance of parent class"""
         super().__init__(project_slug, keyvault_alias)
@@ -95,7 +98,7 @@ def send_via_ftps(
     ) -> None:
         """Send the zip content to the FTPS server."""
         # Create the remote directory if it doesn't exist
-        ftp = _connect_to_ftp(self.host, self.port, self.user, self.password)
+        ftp = _connect_to_ftp(self.host, self.port, self.user, self.password, self.ftp_tls_class)
         _create_and_set_as_cwd(ftp, remote_directory)
         command = f"STOR {pseudo_anon_image_id}.zip"
         logger.debug("Running {}", command)
@@ -133,7 +136,7 @@ def upload_parquet_files(self, parquet_export: ParquetExport) -> None:
 
         source_root_dir = parquet_export.current_extract_base
         # Create the remote directory if it doesn't exist
-        ftp = _connect_to_ftp(self.host, self.port, self.user, self.password)
+        ftp = _connect_to_ftp(self.host, self.port, self.user, self.password, self.ftp_tls_class)
         _create_and_set_as_cwd(ftp, parquet_export.project_slug)
         _create_and_set_as_cwd(ftp, parquet_export.extract_time_slug)
         _create_and_set_as_cwd(ftp, "parquet")
@@ -168,10 +171,22 @@ def upload_parquet_files(self, parquet_export: ParquetExport) -> None:
         logger.info("Finished FTPS upload of files for '{}'", parquet_export.project_slug)
 
 
-def _connect_to_ftp(ftp_host: str, ftp_port: int, ftp_user: str, ftp_password: str) -> FTP_TLS:
+class FTPESUploader(FTPSUploader):
+    """Upload strategy for an FTPES server (explicit rather than implicit TLS)."""
+
+    ftp_tls_class = ftplib.FTP_TLS
+
+
+def _connect_to_ftp(
+    ftp_host: str,
+    ftp_port: int,
+    ftp_user: str,
+    ftp_password: str,
+    ftp_tls_class: type[ftplib.FTP_TLS],
+) -> FTP_TLS:
     # Connect to the server and login
     try:
-        ftp = ImplicitFtpTls()
+        ftp = ftp_tls_class()
         ftp.connect(ftp_host, int(ftp_port))
         ftp.login(ftp_user, ftp_password)
         ftp.prot_p()
diff --git a/pixl_dcmd/src/pixl_dcmd/main.py b/pixl_dcmd/src/pixl_dcmd/main.py
index 95b73c92..8fbbfad3 100644
--- a/pixl_dcmd/src/pixl_dcmd/main.py
+++ b/pixl_dcmd/src/pixl_dcmd/main.py
@@ -262,7 +262,11 @@ def _clean_dicom_image_pixels(
     burned_pixels = has_burned_pixels(dataset, deid=deid_recipe)
     cleaned_pixels = clean_pixel_data(dicom_file=dataset, results=burned_pixels)
 
-    dataset.PixelData = cleaned_pixels.tobytes()
+    pixel_bytes = cleaned_pixels.tobytes()
+    if dataset.file_meta.TransferSyntaxUID.is_compressed:
+        dataset.PixelData = pydicom.encaps.encapsulate([pixel_bytes])
+    else:
+        dataset.PixelData = pixel_bytes
 
 
 def _anonymise_dicom_from_scheme(
diff --git a/projects/configs/tag-operations/us.yaml b/projects/configs/tag-operations/us.yaml
index f755dfbc..77a66c89 100644
--- a/projects/configs/tag-operations/us.yaml
+++ b/projects/configs/tag-operations/us.yaml
@@ -23,4 +23,48 @@
 - name: Sequence of Ultrasound Regions
   group: 0x0018
   element: 0x6011
-  op: keep
\ No newline at end of file
+  op: keep
+- name: Region Spatial Format
+  group: 0x0018
+  element: 0x6012
+  op: keep
+- name: Region Data Type
+  group: 0x0018
+  element: 0x6014
+  op: keep
+- name: Region Flags
+  group: 0x0018
+  element: 0x6016
+  op: keep
+- name: Region Location Min X0
+  group: 0x0018
+  element: 0x6018
+  op: keep
+- name: Region Location Min Y0
+  group: 0x0018
+  element: 0x601A
+  op: keep
+- name: Region Location Max X1
+  group: 0x0018
+  element: 0x601C
+  op: keep
+- name: Region Location Max Y1
+  group: 0x0018
+  element: 0x601E
+  op: keep
+- name: Physical Units X Direction
+  group: 0x0018
+  element: 0x6024
+  op: keep
+- name: Physical Units Y Direction
+  group: 0x0018
+  element: 0x6026
+  op: keep
+- name: Physical Delta X
+  group: 0x0018
+  element: 0x602C
+  op: keep
+- name: Physical Delta Y
+  group: 0x0018
+  element: 0x602E
+  op: keep
diff --git a/projects/configs/ultrasound-learning-for-timely-rapid-assessment-of-cts.yaml b/projects/configs/ultrasound-learning-for-timely-rapid-assessment-of-cts.yaml
index 883b52c2..d43ca880 100644
--- a/projects/configs/ultrasound-learning-for-timely-rapid-assessment-of-cts.yaml
+++ b/projects/configs/ultrasound-learning-for-timely-rapid-assessment-of-cts.yaml
@@ -39,5 +39,5 @@ series_filters:
     - "positioning"
 
 destination:
-    dicom: "ftps"
-    parquet: "ftps"
+    dicom: "ftpes"
+    parquet: "ftpes"