diff --git a/docs/uv.md b/docs/uv.md
index ac8b14f27..6de057026 100644
--- a/docs/uv.md
+++ b/docs/uv.md
@@ -421,6 +421,13 @@ gazelle_python_manifest(
 - `include_stub_packages` — Whether to index conventional stub distributions such as
   `types-requests` and `asyncpg-stubs`. The Gazelle Python extension then adds matching
   stub dependencies automatically. Defaults to `False`.
+- `platform_parents` — Single-element list holding the parent platform for the synthetic
+  platforms this rule uses to pin each venv's dependency group (Bazel's `platform()` rule
+  accepts at most one parent). Defaults to `["@platforms//host"]`, which carries only bare
+  OS and CPU constraints. Set it when that isn't enough: pass your custom `--host_platform`
+  when hermetic C++ toolchains gate on extra constraints, so sdist builds in the hub can
+  still resolve a cc toolchain; or pass the target platform when cross-compiling, so wheel
+  selection follows it instead of snapping back to the host.
 - `venvs` — List of dependency group names whose wheels should be indexed. Module mappings
   from all listed dependency groups are merged into a single manifest.
 
diff --git a/e2e/cases/BUILD.bazel b/e2e/cases/BUILD.bazel
index f5ebd0dd9..bac80e1a4 100644
--- a/e2e/cases/BUILD.bazel
+++ b/e2e/cases/BUILD.bazel
@@ -241,5 +241,18 @@ write_source_files(
         # modules_mapping so generator drift (module additions, stub
         # synthesis, merge ordering) surfaces as a diff.
         "snapshots/uv_gazelle_778.gazelle_python.yaml": "//uv-gazelle-778:gazelle_python_manifest",
+
+        # Gazelle manifest built by //gazelle-platform-parents-1416 with a
+        # caller-supplied `platform_parents` (issue #1416). Pins that the
+        # manifest builds end-to-end when the macro's synthetic per-venv
+        # platforms parent onto a custom platform rather than
+        # `@platforms//host`.
+        "snapshots/gazelle_platform_parents_1416.gazelle_python.yaml": "//gazelle-platform-parents-1416:gazelle_python_manifest",
+        # Companion probe: a genrule transitioned onto the macro-generated
+        # platform, selecting on a constraint only the custom parent carries.
+        # Pins "custom-parent": if the macro ignores `platform_parents` the
+        # constraint is dropped and the diff test fails, rather than the
+        # regression silently building.
+        "snapshots/gazelle_platform_parents_1416.probe_out.txt": "//gazelle-platform-parents-1416:probe",
     },
 )
diff --git a/e2e/cases/gazelle-platform-parents-1416/BUILD.bazel b/e2e/cases/gazelle-platform-parents-1416/BUILD.bazel
new file mode 100644
index 000000000..dd01c2665
--- /dev/null
+++ b/e2e/cases/gazelle-platform-parents-1416/BUILD.bazel
@@ -0,0 +1,65 @@
+load("@aspect_rules_py//uv:defs.bzl", "gazelle_python_manifest")
+load("@bazel_lib//lib:transitions.bzl", "platform_transition_filegroup")
+
+# Regression test for `gazelle_python_manifest(platform_parents = ...)`
+# (issue #1416: the macro's synthetic per-venv platforms were pinned to
+# `@platforms//host`, breaking cross-compilation and custom host platforms).
+# Reads from the //uv-deps-650 hub, which already declares an `extras` venv.
+#
+# Documented exception to per-case isolation: this test applies Gazelle to a
+# venv from another case (//uv-deps-650), so the cross-case reference is by
+# design.
+package(default_visibility = ["//:__pkg__"])
+
+# A case-local constraint that only `:parent_platform` carries: observing it
+# downstream proves the macro-generated platform inherited from
+# `:parent_platform`.
+constraint_setting(name = "parentage")
+
+constraint_value(
+    name = "custom_parent",
+    constraint_setting = ":parentage",
+)
+
+# Stands in for a user's custom `--host_platform` — e.g. one carrying the extra
+# constraints a hermetic C++ toolchain gates on. Parenting it on
+# `@platforms//host` keeps the case host-OS-agnostic.
+platform(
+    name = "parent_platform",
+    constraint_values = [":custom_parent"],
+    parents = ["@platforms//host"],
+)
+
+gazelle_python_manifest(
+    name = "gazelle_python_manifest",
+    hub = "pypi_uv_deps_650",
+    platform_parents = [":parent_platform"],
+    venvs = ["extras"],
+)
+
+# The macro generates a synthetic platform named `_{name}_{hub}_{venv}` in
+# this package; `:probe` depends on that naming scheme, so a rename inside the
+# macro breaks this target with a missing-target analysis error.
+#
+# The snapshot pins "custom-parent": if the macro ignores `platform_parents`,
+# the generated platform loses `:custom_parent`, the select falls through to
+# "default-parent", and the snapshot diff test fails.
+config_setting(
+    name = "under_custom_parent",
+    constraint_values = [":custom_parent"],
+)
+
+genrule(
+    name = "probe_src",
+    outs = ["probe_out.txt"],
+    cmd = select({
+        ":under_custom_parent": "echo custom-parent > $@",
+        "//conditions:default": "echo default-parent > $@",
+    }),
+)
+
+platform_transition_filegroup(
+    name = "probe",
+    srcs = [":probe_src"],
+    target_platform = ":_gazelle_python_manifest_pypi_uv_deps_650_extras",
+)
diff --git a/e2e/cases/snapshots/gazelle_platform_parents_1416.gazelle_python.yaml b/e2e/cases/snapshots/gazelle_platform_parents_1416.gazelle_python.yaml
new file mode 100644
index 000000000..e4d43618d
--- /dev/null
+++ b/e2e/cases/snapshots/gazelle_platform_parents_1416.gazelle_python.yaml
@@ -0,0 +1,18 @@
+manifest:
+  modules_mapping:
+    brotli: brotli
+    brotlicffi: brotlicffi
+    build: build
+    certifi: certifi
+    cffi: cffi
+    charset_normalizer: charset_normalizer
+    colorama: colorama
+    idna: idna
+    packaging: packaging
+    pycparser: pycparser
+    pyproject_hooks: pyproject_hooks
+    requests: requests
+    setuptools: setuptools
+    urllib3: urllib3
+  pip_repository:
+    name: pypi_uv_deps_650
diff --git a/e2e/cases/snapshots/gazelle_platform_parents_1416.probe_out.txt b/e2e/cases/snapshots/gazelle_platform_parents_1416.probe_out.txt
new file mode 100644
index 000000000..a3838b087
--- /dev/null
+++ b/e2e/cases/snapshots/gazelle_platform_parents_1416.probe_out.txt
@@ -0,0 +1 @@
+custom-parent
diff --git a/uv/private/gazelle_manifest/defs.bzl b/uv/private/gazelle_manifest/defs.bzl
index 25d0727b9..3186a2f3b 100644
--- a/uv/private/gazelle_manifest/defs.bzl
+++ b/uv/private/gazelle_manifest/defs.bzl
@@ -70,7 +70,12 @@ _modules_mapping = rule(
 
 update = Label(":update.sh")
 
-def gazelle_python_manifest(name, hub, venvs = [], include_stub_packages = False):
+def gazelle_python_manifest(
+        name,
+        hub,
+        venvs = [],
+        include_stub_packages = False,
+        platform_parents = None):
     """Generates a Gazelle Python manifest from uv-managed wheels.
 
     Args:
@@ -79,7 +84,27 @@ def gazelle_python_manifest(name, hub, venvs = [], include_stub_packages = False
         venvs: Dependency groups whose wheels should be indexed.
         include_stub_packages: Whether conventional stub distributions should be
             indexed for Gazelle's automatic stub dependency resolution.
+        platform_parents: Single-element list holding the parent platform for the
+            synthetic platforms this macro uses to select each venv's wheels.
+            (Bazel's `platform()` rule accepts at most one parent; the list shape
+            mirrors its `parents` attribute.) Defaults to
+            `[Label("@platforms//host")]`, resolved in rules_py's own repository —
+            you do not need a `bazel_dep` on `platforms` to use the default. The
+            host platform carries only OS and CPU constraints; point this at the
+            platform the wheels should be resolved for when that is not enough:
+
+            - If the build sets a custom `--host_platform` (for example to carry
+              the constraints hermetic C++ toolchains require), pass that
+              platform here so sdist builds inside the hub can still resolve a
+              cc toolchain.
+            - When cross-compiling, pass the target platform so wheel selection
+              follows it instead of snapping back to the host.
     """
+    if platform_parents == None:
+        platform_parents = [Label("@platforms//host")]
+    if len(platform_parents) != 1:
+        fail("gazelle_python_manifest: platform_parents must contain exactly one platform label (Bazel's platform() rule accepts at most one parent); got {}".format(platform_parents))
+
     file = "gazelle_python.yaml"
     hub = hub.lstrip("@")
 
@@ -88,9 +113,7 @@ def gazelle_python_manifest(name, hub, venvs = [], include_stub_packages = False
         platform_name = "_{}_{}_{}".format(name, hub, venv)
         native.platform(
             name = platform_name,
-            parents = [
-                "@platforms//host",
-            ],
+            parents = platform_parents,
             flags = [
                 "--@{}//dep_group={}".format(hub, venv),
             ],