Great to find a Python implementation of the cipher Qarma.
In the publication of Qarma (https://eprint.iacr.org/2016/444.pdf) they check 3 MC variants: MC4,1 MC4,2 and MC4.3. On page 14 they choose for MC4,2. Maybe you want to add MC4,2 to the Python implementation.
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UsedMixColumns = MixColumns_M43 |