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<!DOCTYPE html>
<html lang="en">
<head>
<title>Ze Tang - Publications</title>
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
<meta name="author" content="Miaozhu Li and Ze Tang">
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<h2>Ze Tang</h2>
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<h2 class="title">Publications</h2>
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<div class="pitems">
<div class="item mix jpaper" data-year="2013">
<div class="pubmain">
<div class="pubassets"> <a href="#" class="pubcollapse"> <i class="icon fa fa-ellipsis-h"></i> </a> <a href="http://doi:10.1371/journal.pone.0066263" class="tooltips" title="External link" target="_blank"> <i class="icon fa fa-external-link"></i> </a> <a href="papers/journal.pone.0066263.pdf" class="tooltips" title="Download" target="_blank"> <i class="icon fa fa-cloud-download"></i> </a> </div>
<h4 class="pubtitle">Porous Tantalum Coatings Prepared by Vacuum Plasma Spraying Enhance BMSCs Osteogenic Differentiation and Bone Regeneration In Vitro and In Vivo</h4>
<div class="pubauthor"><strong>Ze Tang</strong>, Youtao Xie, Fei Yang, Yan Huang, Chuandong Wang, Kerong Dai, Xuebin Zheng, Xiaoling Zhang</div>
<div class="pubcite"><span class="label label-success">Journal Paper</span> PLoS ONE, 8(6): e66263</div>
</div>
<div class="pubdetails">
<h4>Abstract</h4>
<p>Tantalum, as a potential metallic implant biomaterial, is attracting more and more attention because of its excellent anticorrosion and biocompatibility. However, its significantly high elastic modulus and large mechanical incompatibility with bone tissue make it unsuitable for load-bearing implants. In this study, porous tantalum coatings were first successfully fabricated on titanium substrates by vacuum plasma spraying (VPS), which would exert the excellent biocompatibility of tantalum and alleviate the elastic modulus of tantalum for bone tissue. We evaluated cytocompatibility and osteogenesis activity of the porous tantalum coatings using human bone marrow stromal cells (hBMSCs) and its ability to repair rabbit femur bone defects. The morphology and actin cytoskeletons of hBMSCs were observed via electron microscopy and confocal, and the cell viability, proliferation and osteogenic differentiation potential of hBMSCs were examined quantitatively by PrestoBlue assay, Ki67 immunofluorescence assay, real-time PCR technology and ALP staining. For in vivo detection, the repaired femur were evaluated by histomorphology and double fluorescence labeling 3 months postoperation. Porous tantalum coating surfaces promoted hBMSCs adhesion, proliferation, osteogenesis activity and had better osseointegration and faster new bone formation rate than titanium coating control. Our observation suggested that the porous tantalum coatings had good biocompatibility and could enhance osseoinductivity in vitro and promote new bone formation in vivo. The porous tantalum coatings prepared by VPS is a promising strategy for bone regeneration.</p>
</div>
</div>
<div class="item mix patent" data-year="2013">
<div class="pubmain">
<div class="pubassets"> <a href="#" class="pubcollapse"> <i class="icon fa fa-ellipsis-h"></i> </a> <a href="https://www.google.com/patents/CN104127913A?cl=en" class="tooltips" title="External link" target="_blank"> <i class="icon fa fa-external-link"></i> </a> </div>
<h4 class="pubtitle">Medical composite material with improved osseointegration performance</h4>
<div class="pubauthor">Xiaoling Zhang, Youtao Xie, <strong>Ze Tang</strong>, Kerong Dai</div>
<div class="pubcite"><span class="label label-success">Patent</span>Application No. CN 201310163527, May 3, 2013, Publication No. CN104127913 A, Nov 5, 2014. Patent Pending</div>
</div>
<div class="pubdetails">
<h4>Abstract</h4>
<p>The invention provides a medical composite material with improved osseointegration performance. Specifically speaking, the medical composite material comprises a substrate and a coating which coats the substrate, wherein the coating is a Ta coating. The medical composite material has good mechanical performance and osseointegration performance, so the medical composite material is especially applicable to preparation of medical grafts and has wide application prospects.</p>
</div>
</div>
<div class="item mix jpaper" data-year="2012">
<div class="pubmain">
<div class="pubassets"> <a href="#" class="pubcollapse"> <i class="icon fa fa-ellipsis-h"></i> </a> <a href="http://dx.doi.org/10.1016/j.canlet.2012.06.006" class="tooltips" title="External link" target="_blank"> <i class="icon fa fa-external-link"></i> </a> </div>
<h4 class="pubtitle">TAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma</h4>
<div class="pubauthor">Bing Tu, Lin Du, Qi-Ming Fan, <strong>Ze Tang</strong>, Ting-Ting Tang</div>
<div class="pubcite"><span class="label label-success">Journal Paper</span> Cancer Lett, 2012. 325(1): p. 80-8</div>
</div>
<div class="pubdetails">
<h4>Abstract</h4>
<p>We previously demonstrated that human mesenchymal stem cells (MSCs) promote the growth of osteosarcoma in the bone microenvironment. The aim of the present study was to further determine the effect of IL-6/STAT3 signaling on the progression of osteosarcoma. First, conditioned medium from MSCs was used to stimulate the growth of osteosarcoma cells (Saos-2) in vitro. We found that STAT3 was activated and that the activation could be blocked by an IL-6-neutralizing antibody. The inhibition of STAT3 in Saos-2 cells by siRNA or AG490 decreased cell proliferation, migration and invasion, down-regulated the mRNA expression of Cyclin D, Bcl-xL and Survivin and enhanced the apoptotic response. Furthermore, a nude mouse osteosarcoma model was established by injecting luciferase-labeled Saos-2 cells into the tibia, and the effect of STAT3 on tumor growth was determined by treating the mice with AG490. In vivo bioluminescence images showed that tumor growth was dramatically reduced in the AG490 group. In addition, STAT3 inhibition decreased the lung metastasis rate and prolonged the survival of these mice. After treatment with AG490, the protein levels of IL-6, p-STAT3 and PCNA were decreased, and the level of apoptosis in the tumor was increased. Altogether, these data indicate that MSCs in the bone microenvironment might promote the progression of osteosarcoma and protect tumor cells from drug-induced apoptosis through IL-6/STAT3 signaling.</p>
</div>
</div>
<div class="item mix jpaper" data-year="2010">
<div class="pubmain">
<div class="pubassets"> <a href="#" class="pubcollapse"> <i class="icon fa fa-ellipsis-h"></i> </a> <a href="http://dx.doi.org/10.1088/1748-6041/5/4/045005" class="tooltips" title="External link" target="_blank"> <i class="icon fa fa-external-link"></i> </a> </div>
<h4 class="pubtitle">Effects of magnesium alloys extracts on adult human bone marrow-derived stromal cell viability and osteogenic differentiation</h4>
<div class="pubauthor">Chunxi Yang, Guangyin Yuan, Jia Zhang, <strong>Ze Tang</strong>, Xiaoling Zhang, Kerong Dai</div>
<div class="pubcite"><span class="label label-success">Journal Paper</span> Biomed Mater, 2010. 5(4): p. 045005</div>
</div>
<div class="pubdetails">
<h4>Abstract</h4>
<p>In this study, adult human bone marrow-derived stromal cells (hBMSCs) were cultured in extracts of magnesium (Mg) and the Mg alloys AZ91D and NZ30K for 12 days. We studied the indirect effects of Mg alloys on hBMSC viability. Alkaline phosphatase activity and the expression of osteogenic differentiation marker genes were used to evaluate the effects of the Mg alloys on the osteogenic differentiation of hBMSCs. The results indicate that <or=10 mM concentration of Mg in the extracts did not inhibit the viability and osteogenic differentiation of hBMSCs. However, the results suggest that the high pH of the extracts, which is a result of the rapid corrosion of Mg and the Mg alloys, is unfavorable to the viability and osteogenic differentiation of hBMSCs.</p>
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