diff --git a/archives/prospr_core.tar.gz b/archives/prospr_core.tar.gz
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diff --git a/archives/prospr_core.zip b/archives/prospr_core.zip
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diff --git a/archives/prospr_data.tar.gz b/archives/prospr_data.tar.gz
index 4a48a2c..ce7ffcc 100644
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diff --git a/archives/prospr_data.zip b/archives/prospr_data.zip
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diff --git a/docs/source/api.rst b/docs/source/api.rst
index cd8e562..855536f 100644
--- a/docs/source/api.rst
+++ b/docs/source/api.rst
@@ -35,6 +35,24 @@ specifying a submodule, e.g.
     |     *Does not reset the Protein properties beforehand!*
     |         *Parameters:*
     |             * **protein** - *Protein*: the Protein object to fold.
+    |             * **prune_func** - *str*: "naive_prune" (default) or "reach_prune".
+    |             * **is_pre_folded** - *bool*: If _True_, the partial hash
+                    of the protein will not be reset (Default is _False_.)
+    |         *Returns:*
+    |             * **Protein** - the Protein object set at the found
+                    conformation and with updated properties according to the
+                    performed moves.
+
+    | **depth_first_bnb_parallel**\ (*protein*)
+    |     Finds the most optimal conformation using a depth-first
+          branch-and-bound algorithm.
+    |     Multiple subtrees are enumerated and solved in parallel using OpenMP.
+    |     *Does not reset the Protein properties beforehand!*
+    |         *Parameters:*
+    |             * **protein** - *Protein*: the Protein object to fold.
+    |             * **prune_func** - *str*: "naive_prune" (default) or "reach_prune".
+    |             * **work_ratio** - *float*: The number of subtrees per thread to aim for.
+                    Too low/high values may result in degraded performance. (Default is 3.)
     |         *Returns:*
     |             * **Protein** - the Protein object set at the found
                     conformation and with updated properties according to the
diff --git a/prospr/__init__.py b/prospr/__init__.py
index 05c0cbf..d82334b 100644
--- a/prospr/__init__.py
+++ b/prospr/__init__.py
@@ -5,6 +5,7 @@
     Protein,
     depth_first,
     depth_first_bnb,
+    depth_first_bnb_parallel,
     beam_search,
 )
 from .datasets import load_vanEck250, load_vanEck1000, load_vanEck_hratio
@@ -20,6 +21,7 @@
     "Protein",
     "depth_first",
     "depth_first_bnb",
+    "depth_first_bnb_parallel",
     "beam_search",
     "load_vanEck250",
     "load_vanEck1000",
diff --git a/prospr/core/core_module.cpp b/prospr/core/core_module.cpp
index 96d1613..93b605e 100644
--- a/prospr/core/core_module.cpp
+++ b/prospr/core/core_module.cpp
@@ -84,7 +84,13 @@ PYBIND11_MODULE(prospr_core, m) {
   m.def("depth_first_bnb", depth_first_bnb,
         "Finds the optimal conformation via depth-first branch-and-bound "
         "search",
-        py::arg("protein"), py::arg("prune_func") = "");
+        py::arg("protein"), py::arg("prune_func") = "", py::arg("is_pre_folded") = false);
+
+  /* Parallel depth-first branch-and-bound search function definition. */
+  m.def("depth_first_bnb_parallel", depth_first_bnb_parallel,
+        "Finds the optimal conformation via depth-first branch-and-bound "
+        "search using OpenMP and multiple subtrees",
+        py::arg("protein"), py::arg("prune_func") = "", py::arg("work_ratio") = 3);
 
   /* Beam search function definition. */
   m.def("beam_search", beam_search,
diff --git a/prospr/core/src/depth_first_bnb.cpp b/prospr/core/src/depth_first_bnb.cpp
index fba8a8e..9f28925 100644
--- a/prospr/core/src/depth_first_bnb.cpp
+++ b/prospr/core/src/depth_first_bnb.cpp
@@ -11,10 +11,16 @@
 #include <math.h>
 
 #include <algorithm>
+#include <functional>
+#include <iostream>
 #include <numeric>
 #include <stack>
 #include <vector>
 
+#ifdef _OPENMP
+#include <omp.h>
+#endif
+
 /* All possible variables required by custom pruning. */
 struct prune_vars {
   size_t max_length;
@@ -93,17 +99,20 @@ bool reach_prune(Protein *protein, int move, int best_score,
 /* A depth-first branch-and-bound search function for finding a minimum
  * energy conformation.
  */
-void depth_first_bnb(Protein *protein, std::string prune_func) {
-  protein->reset_conformation();
+void depth_first_bnb(Protein *protein, std::string prune_func, bool is_pre_folded) {
+  if (!is_pre_folded)
+    protein->reset_conformation();
   size_t max_length = protein->get_sequence().length();
   int dim = protein->get_dim();
   size_t no_neighbors = (size_t)pow(2, (dim - 1));
 
-  /* The first two amino acids are fixed to prevent y-axis symmetry. */
-  if (max_length > 1)
-    protein->place_amino(-1);
-  if (max_length <= 2)
-    return;
+  if (!is_pre_folded) {
+    /* The first two amino acids are fixed to prevent y-axis symmetry. */
+    if (max_length > 1)
+      protein->place_amino(-1);
+    if (max_length <= 2)
+      return;
+  }
 
   /* Init default prune functions and arguments. */
   auto prune_branch = naive_prune;
@@ -154,9 +163,13 @@ void depth_first_bnb(Protein *protein, std::string prune_func) {
 
   /* Declare and set variables for the depth-first search. */
   bool placed_amino = false;
-  int best_score = 1;
+  int best_score = 1; protein->get_score();
   int score;
-  std::vector<int> best_hash;
+  std::vector<int> best_hash = protein->hash_fold();
+  if (is_pre_folded) {
+    best_score = protein->get_score();
+    best_hash = protein->hash_fold();
+  }
 
   do {
     placed_amino = false;
@@ -214,6 +227,89 @@ void depth_first_bnb(Protein *protein, std::string prune_func) {
     }
   } while (move != -dim - 1 || !dfs_stack.empty());
 
+  /* Complete hash with "straight line" */
+  while (best_hash.size() < max_length - 1)
+    best_hash.push_back(best_hash.back());
   /* Set best found conformation and return protein. */
   protein->set_hash(best_hash);
 }
+
+/* Iterate all valid leaf nodes of pre-folded proteins at a certain depth
+ * (limited to tree depth).
+ */
+std::vector<Protein> pre_fold(Protein* protein, size_t depth) {
+  std::vector<Protein> pre_folded;
+  const int dim = protein->get_dim();
+  const size_t max_length = protein->get_sequence().length();
+  std::function<void(const Protein&, size_t)> pre_fold_recurse;
+  pre_fold_recurse = [&](const Protein& protein, size_t recurse) {
+    for(int move = -dim; move <= dim; move++) {
+      if(move == 0) continue;
+      if(!protein.is_valid(move)) continue;
+      Protein next(protein);
+      next.place_amino(move);
+      if(recurse)
+        pre_fold_recurse(next, recurse - 1);
+      else
+        pre_folded.push_back(next);
+    }
+  };
+  Protein root(*protein);
+  root.reset_conformation();
+  /* The first two amino acids are fixed to prevent y-axis symmetry. */
+  if (max_length > 1)
+    root.place_amino(-1);
+  depth = std::min(max_length, depth) - 1;
+  if(depth > 0)
+    pre_fold_recurse(root, depth - 1);
+  else
+    pre_folded.push_back(root);
+  return pre_folded;
+}
+
+/* A depth-first branch-and-bound search function for finding a minimum energy
+ * conformation using OpenMP to explore multiple subtrees in parallel.
+ */
+void depth_first_bnb_parallel(Protein *protein, std::string prune_func, float work_ratio) {
+#ifdef _OPENMP
+  int workerCount;
+  #pragma omp parallel
+  #pragma omp single
+  {
+    workerCount = omp_get_num_threads();
+  }
+  float targetSubtreeCount = (float)(workerCount) * work_ratio;
+  /* Each node has up to 3 child nodes -> determine closest depth to match work_ratio */
+  size_t pre_fold_depth = (size_t)std::max(0ll, llround(log(targetSubtreeCount) / log(3.0)));
+  auto pre_folded = pre_fold(protein, pre_fold_depth);
+
+  /*TODO: Consider sharing a reference to best_score between threads for better pruning.
+   *      (Requires atomic compare-and-update.)
+   */
+  int best_score = 1;
+  std::vector<int> best_hash;
+  #pragma omp parallel for schedule(dynamic) shared(best_score, best_hash)
+  for(int i = 0; i < (int) pre_folded.size(); i++) {
+    Protein& candidate_protein = pre_folded[i];
+    depth_first_bnb(&candidate_protein, prune_func, true);
+    int score = candidate_protein.get_score();
+    #pragma omp critical
+    {
+      if(score < best_score) {
+        best_score = score;
+        best_hash = candidate_protein.hash_fold();
+        protein->aminos_placed += candidate_protein.get_aminos_placed();
+        protein->solutions_checked += candidate_protein.get_solutions_checked();
+      }
+    }
+  }
+  protein->set_hash(best_hash);
+#else
+  static bool warned = false;
+  if (!warned) {
+      std::cerr << "Warning: Built without OpenMP support. Using serial depth_first_bnb(...) instead.\n";
+      warned = true;
+  }
+  depth_first_bnb(protein, prune_func);
+#endif
+}
diff --git a/prospr/core/src/depth_first_bnb.hpp b/prospr/core/src/depth_first_bnb.hpp
index 74b5915..d280785 100644
--- a/prospr/core/src/depth_first_bnb.hpp
+++ b/prospr/core/src/depth_first_bnb.hpp
@@ -14,6 +14,11 @@
 /* A depth-first branch-and-bound search function for finding a minimum energy
  * conformation.
  */
-void depth_first_bnb(Protein *protein, std::string prune_func = "");
+void depth_first_bnb(Protein *protein, std::string prune_func = "", bool is_pre_folded = false);
+
+/* A depth-first branch-and-bound search function for finding a minimum energy
+ * conformation using OpenMP to explore multiple subtrees in parallel.
+ */
+void depth_first_bnb_parallel(Protein *protein, std::string prune_func = "", float work_ratio = 3);
 
 #endif
diff --git a/prospr/core/src/protein.cpp b/prospr/core/src/protein.cpp
index 62eb2a3..bb80570 100644
--- a/prospr/core/src/protein.cpp
+++ b/prospr/core/src/protein.cpp
@@ -277,7 +277,7 @@ void Protein::reset_conformation() {
 }
 
 /* Returns true if a move is valid, returns false otherwise. */
-bool Protein::is_valid(int move) {
+bool Protein::is_valid(int move) const {
   std::vector<int> check_pos = last_pos;
   check_pos[abs(move) - 1] += move / abs(move);
 
diff --git a/prospr/core/src/protein.hpp b/prospr/core/src/protein.hpp
index 93f3513..70f894a 100644
--- a/prospr/core/src/protein.hpp
+++ b/prospr/core/src/protein.hpp
@@ -82,7 +82,7 @@ class Protein {
   void reset_conformation();
 
   /* Returns true if a move is valid, returns false otherwise. */
-  bool is_valid(int move);
+  bool is_valid(int move) const;
 
   /* Place the next amino acid and update the conformation accordingly. */
   void place_amino(int move, bool track = true);
@@ -125,6 +125,9 @@ class Protein {
   std::vector<std::pair<int, int>>
   _append_bond_pairs(std::vector<std::pair<int, int>> pairs,
                      std::vector<int> pos, std::vector<int> moves);
+
+  /* Private member access required to merge statistics of subtree solutions */
+  friend void depth_first_bnb_parallel(Protein *protein, std::string prune_func, float work_ratio);
 };
 
 /* Overload << operator for printing Proteins. */
diff --git a/prospr/core/tests/run_tests.sh b/prospr/core/tests/run_tests.sh
index 40aac50..bdceaa0 100755
--- a/prospr/core/tests/run_tests.sh
+++ b/prospr/core/tests/run_tests.sh
@@ -10,7 +10,7 @@ set -e
 
 SCRIPT_DIR=$( cd -- "$( dirname -- "${BASH_SOURCE[0]}" )" &> /dev/null && pwd )
 CFLAGS="-o3 -g -Wall -Wextra -Wconversion -Wcast-align -std=c++11
-    -Wunreachable-code"
+    -Wunreachable-code -fopenmp"
 DEBUG=""
 VALGRIND=""
 
@@ -122,6 +122,7 @@ test_all() {
     test_protein
     test_depth_first
     test_depth_first_bnb
+    test_depth_first_bnb_parallel
     test_beam_search
 }
 
diff --git a/prospr/core/tests/test_algorithms.cpp b/prospr/core/tests/test_algorithms.cpp
index 6b7bd46..79b2885 100644
--- a/prospr/core/tests/test_algorithms.cpp
+++ b/prospr/core/tests/test_algorithms.cpp
@@ -56,6 +56,16 @@ void test_depth_first_bnb() {
   assert(protein->get_score() == -4);
   delete protein;
   std::cout << "\t3D Protein solution scores matches.\n";
+
+  /* Check if parallel algorithm solutions are found correctly. */
+  protein = new Protein("PHPHPHPPH", 2, "HP");
+  depth_first_bnb_parallel(protein);
+  int score = protein->get_score();
+  protein->reset();
+  depth_first_bnb(protein);
+  assert(score == protein->get_score());
+  delete protein;
+  std::cout << "\t2D Protein solution scores matches between parallel and serial algorithms.\n";
 }
 
 /* Test functionality of depth_first_bnb. */
diff --git a/setup.py b/setup.py
index d6f571f..88d9f72 100644
--- a/setup.py
+++ b/setup.py
@@ -8,15 +8,37 @@
                 specifics.
 """
 
+import os
+import sys
 from setuptools import setup
 from pybind11.setup_helpers import Pybind11Extension, build_ext
 
 
+compile_args = []
+link_args = []
+
+if sys.platform == "darwin":
+    # macOS: Requires libomp installed via brew install libomp
+    use_omp = os.environ.get("MAC_USE_LOMP", "0") == "1"
+    if use_omp:
+        compile_args.append("-Xpreprocessor -fopenmp")
+        link_args.extend(["-lomp"])
+    else:
+        print("Warning: OpenMP is not enabled on macOS by default."
+              " Set MAC_USE_LOMP=1 to enable it.", file=sys.stderr)
+elif sys.platform == "linux":
+    compile_args.append("-fopenmp")
+    link_args.append("-fopenmp")
+elif sys.platform == "win32":
+    compile_args.append("/openmp")
+
 setup(
     ext_modules=[
         Pybind11Extension(
             name="prospr_core",
             sources=["prospr/core/core_module.cpp"],
+            extra_compile_args=compile_args,
+            extra_link_args=link_args,
             language="c++",
         ),
     ],
diff --git a/tests/core/test_depth_first_bnb.py b/tests/core/test_depth_first_bnb.py
index 51c3af7..6ee4be6 100644
--- a/tests/core/test_depth_first_bnb.py
+++ b/tests/core/test_depth_first_bnb.py
@@ -8,7 +8,7 @@
                 specifics.
 """
 
-from prospr import Protein, depth_first_bnb
+from prospr import Protein, depth_first_bnb, depth_first_bnb_parallel
 import pytest
 
 
@@ -50,3 +50,14 @@ def test_protein_3d_depth_first_bnb(self, protein_3d):
         assert protein_3d.score == -4
         assert protein_3d.solutions_checked == 5
         assert protein_3d.aminos_placed == 49368
+
+    
+    def test_protein_2d_depth_first_bnb_parallel(self, protein_2d):
+        """
+        Test if parallel algorithm solution matches serial algorithm.
+        """
+        depth_first_bnb_parallel(protein_2d)
+        score = protein_2d.score
+        protein_2d.reset()
+        depth_first_bnb(protein_2d)
+        assert score == protein_2d.score