Single Variant Meta-analysis Using ReMeta on Existing Regenie Results & htp format

[tpereachamblee]

Hello,

First, thanks for your work on this tool!

A question: Is the htp format a strict requirement for all of the modules of remeta, particularly for doing single variant esma and pvma (this appears to be the case in the documentation and help messages)? If so, why?

I have scanned through the fields of the additional meta-data stored, and appreciate that a few are pieces of information that would only be available to regenie (through the covariates file, phenotypes file, pgen/pvar/psam, or otherwise by calculating) and would not be the standard output, but one could imagine doing these sorts of meta-analysis at the SNP level using only data already found in the usual regenie summary statistics (e.g. METAL).

I guess my concern is that it could be a bit redundant to re-run association tests (across numerous cohorts) to simply produce htp files. However, I may be missing a critical detail.

Thanks for you time,
T