diff --git a/compiler/src/dotty/tools/dotc/Driver.scala b/compiler/src/dotty/tools/dotc/Driver.scala
index f8daabf3ec5d..4102f7b9ee86 100644
--- a/compiler/src/dotty/tools/dotc/Driver.scala
+++ b/compiler/src/dotty/tools/dotc/Driver.scala
@@ -70,6 +70,8 @@ class Driver {
 
   protected def command: CompilerCommand = ScalacCommand
 
+  protected def globalCache: GlobalCache = GlobalCache()
+
   /** Setup context with initialized settings from CLI arguments, then check if there are any settings that
    *  would change the default behaviour of the compiler.
    *
@@ -81,6 +83,7 @@ class Driver {
     val ictx = rootCtx.fresh
     val summary = command.distill(args, ictx.settings)(ictx.settingsState)(using ictx)
     ictx.setSettings(summary.sstate)
+    ictx.setGlobalCache(globalCache)
     MacroClassLoader.init(ictx)
     Positioned.init(using ictx)
 
diff --git a/compiler/src/dotty/tools/dotc/GlobalCache.scala b/compiler/src/dotty/tools/dotc/GlobalCache.scala
new file mode 100644
index 000000000000..2ff9aae46222
--- /dev/null
+++ b/compiler/src/dotty/tools/dotc/GlobalCache.scala
@@ -0,0 +1,62 @@
+package dotty.tools.dotc
+
+import java.nio.file.Files
+import java.nio.file.attribute.BasicFileAttributes
+import java.nio.file.attribute.FileTime
+
+import dotty.tools.dotc.core.Contexts.Context
+import dotty.tools.dotc.core.Decorators.em
+import dotty.tools.dotc.report
+import dotty.tools.io.{AbstractFile, ClassPath}
+
+trait GlobalCache:
+  def getOrCreateClassPath(key: AbstractFile, createValue: => ClassPath)(using Context): ClassPath
+
+/** Global cache that can be shared across [[Driver]] instances.
+ *
+ *  This class is thread-safe.
+ */
+private final class GlobalCacheImpl() extends GlobalCache:
+  private val classPathCache = FileBasedCache[ClassPath]()
+
+  def getOrCreateClassPath(key: AbstractFile, createValue: => ClassPath)(using Context): ClassPath =
+    classPathCache.getOrCreate(key.file.nn.toPath, () => createValue)
+
+object GlobalCache:
+  def apply(): GlobalCache =
+    GlobalCacheImpl()
+
+  object NoGlobalCache extends GlobalCache:
+    def getOrCreateClassPath(key: AbstractFile, createValue: => ClassPath)(using Context): ClassPath =
+      report.configurationWarning(em"Not GlobalCache set")
+      createValue
+
+/** A cache for values associated with files on disk, that invalidates
+ *  the cached value when the file is modified.
+ *
+ *  See https://github.com/scala/bug/issues/10295 for some context on the
+ *  invalidation strategy.
+ *
+ *  Moved from [[ZipAndJarFileLookupFactory]] in December 2025.
+ *
+ *  @author @allanrenucci
+ */
+private class FileBasedCache[T]:
+  private case class Stamp(lastModified: FileTime, fileKey: Object)
+  private val cache = collection.mutable.Map.empty[java.nio.file.Path, (Stamp, T)]
+
+  def getOrCreate(path: java.nio.file.Path, create: () => T): T =
+    cache.synchronized:
+      val attrs = Files.readAttributes(path, classOf[BasicFileAttributes])
+      val lastModified = attrs.lastModifiedTime()
+      // null on some platforms, but that's okay, we just use the last
+      // modified timestamp as our stamp in that case
+      val fileKey = attrs.fileKey()
+      val stamp = Stamp(lastModified, fileKey)
+      cache.get(path) match
+        case Some((cachedStamp, cached)) if cachedStamp == stamp =>
+          cached
+        case _ =>
+          val value = create()
+          cache.put(path, (stamp, value))
+          value
diff --git a/compiler/src/dotty/tools/dotc/classpath/ZipAndJarFileLookupFactory.scala b/compiler/src/dotty/tools/dotc/classpath/ZipAndJarFileLookupFactory.scala
index d5473e6b26c3..a4b693873390 100644
--- a/compiler/src/dotty/tools/dotc/classpath/ZipAndJarFileLookupFactory.scala
+++ b/compiler/src/dotty/tools/dotc/classpath/ZipAndJarFileLookupFactory.scala
@@ -22,17 +22,12 @@ import FileUtils.*
  * when there are a lot of projects having a lot of common dependencies.
  */
 sealed trait ZipAndJarFileLookupFactory {
-  private val cache = new FileBasedCache[ClassPath]
-
   def create(zipFile: AbstractFile)(using Context): ClassPath =
     val release = Option(ctx.settings.javaOutputVersion.value).filter(_.nonEmpty)
     if (ctx.settings.YdisableFlatCpCaching.value || zipFile.file == null) createForZipFile(zipFile, release)
-    else createUsingCache(zipFile, release)
+    else ctx.globalCache.getOrCreateClassPath(zipFile, createForZipFile(zipFile, release))
 
   protected def createForZipFile(zipFile: AbstractFile, release: Option[String]): ClassPath
-
-  private def createUsingCache(zipFile: AbstractFile, release: Option[String]): ClassPath =
-    cache.getOrCreate(zipFile.file.toPath, () => createForZipFile(zipFile, release))
 }
 
 /**
@@ -172,29 +167,3 @@ object ZipAndJarSourcePathFactory extends ZipAndJarFileLookupFactory {
 
   override protected def createForZipFile(zipFile: AbstractFile, release: Option[String]): ClassPath = ZipArchiveSourcePath(zipFile.file)
 }
-
-final class FileBasedCache[T] {
-  private case class Stamp(lastModified: FileTime, fileKey: Object)
-  private val cache = collection.mutable.Map.empty[java.nio.file.Path, (Stamp, T)]
-
-  def getOrCreate(path: java.nio.file.Path, create: () => T): T = cache.synchronized {
-    val attrs = Files.readAttributes(path, classOf[BasicFileAttributes])
-    val lastModified = attrs.lastModifiedTime()
-    // only null on some platforms, but that's okay, we just use the last modified timestamp as our stamp
-    val fileKey = attrs.fileKey()
-    val stamp = Stamp(lastModified, fileKey)
-    cache.get(path) match {
-      case Some((cachedStamp, cached)) if cachedStamp == stamp => cached
-      case _ =>
-        val value = create()
-        cache.put(path, (stamp, value))
-        value
-    }
-  }
-
-  def clear(): Unit = cache.synchronized {
-    // TODO support closing
-    // cache.valuesIterator.foreach(_.close())
-    cache.clear()
-  }
-}
diff --git a/compiler/src/dotty/tools/dotc/core/Contexts.scala b/compiler/src/dotty/tools/dotc/core/Contexts.scala
index 9896cfaa6a1d..ebc1c156a41f 100644
--- a/compiler/src/dotty/tools/dotc/core/Contexts.scala
+++ b/compiler/src/dotty/tools/dotc/core/Contexts.scala
@@ -57,8 +57,9 @@ object Contexts {
   private val (importInfoLoc,        store9) = store8.newLocation[ImportInfo | Null]()
   private val (typeAssignerLoc,     store10) = store9.newLocation[TypeAssigner](TypeAssigner)
   private val (progressCallbackLoc, store11) = store10.newLocation[ProgressCallback | Null]()
+  private val (globalCacheLoc,      store12) = store11.newLocation[GlobalCache]()
 
-  private val initialStore = store11
+  private val initialStore = store12
 
   /** The current context */
   inline def ctx(using ctx: Context): Context = ctx
@@ -189,6 +190,8 @@ object Contexts {
       val local = progressCallback
       if local != null then op(local)
 
+    def globalCache: GlobalCache = store(globalCacheLoc)
+
     /** The current plain printer */
     def printerFn: Context => Printer = store(printerFnLoc)
 
@@ -712,6 +715,7 @@ object Contexts {
     def setCompilerCallback(callback: CompilerCallback): this.type = updateStore(compilerCallbackLoc, callback)
     def setIncCallback(callback: IncrementalCallback): this.type = updateStore(incCallbackLoc, callback)
     def setProgressCallback(callback: ProgressCallback): this.type = updateStore(progressCallbackLoc, callback)
+    def setGlobalCache(globalCache: GlobalCache): this.type = updateStore(globalCacheLoc, globalCache)
     def setPrinterFn(printer: Context => Printer): this.type = updateStore(printerFnLoc, printer)
     def setSettings(settingsState: SettingsState): this.type = updateStore(settingsStateLoc, settingsState)
     def setRun(run: Run | Null): this.type = updateStore(runLoc, run)
@@ -775,6 +779,7 @@ object Contexts {
           .updated(notNullInfosLoc, Nil)
           .updated(compilationUnitLoc, NoCompilationUnit)
           .updated(profilerLoc, Profiler.NoOp)
+          .updated(globalCacheLoc, GlobalCache.NoGlobalCache)
       c._searchHistory = new SearchRoot
       c._gadtState = GadtState(GadtConstraint.empty)
       c
diff --git a/compiler/test/dotty/tools/DottyTest.scala b/compiler/test/dotty/tools/DottyTest.scala
index 76d2fdcb6d26..8bcc1d61a9d6 100644
--- a/compiler/test/dotty/tools/DottyTest.scala
+++ b/compiler/test/dotty/tools/DottyTest.scala
@@ -12,7 +12,7 @@ import dotc.core.Symbols._
 import Types._, Symbols._, Decorators._
 import dotc.core.Decorators._
 import dotc.ast.tpd
-import dotc.Compiler
+import dotc.{Compiler, GlobalCache}
 
 import dotc.core.Phases.Phase
 
@@ -20,6 +20,8 @@ trait DottyTest extends ContextEscapeDetection {
 
   dotc.parsing.Scanners // initialize keywords
 
+  private val globalCache: GlobalCache = GlobalCache()
+
   implicit var ctx: Context = initialCtx
 
   protected def initialCtx: FreshContext = {
@@ -42,6 +44,7 @@ trait DottyTest extends ContextEscapeDetection {
     fc.setSetting(fc.settings.classpath, TestConfiguration.basicClasspath)
     fc.setSetting(fc.settings.language, List("experimental.erasedDefinitions").asInstanceOf)
     fc.setProperty(ContextDoc, new ContextDocstrings)
+    fc.setGlobalCache(globalCache)
   }
 
   protected def defaultCompiler: Compiler = new Compiler()
diff --git a/compiler/test/dotty/tools/dotc/classpath/ZipAndJarFileLookupFactoryTest.scala b/compiler/test/dotty/tools/dotc/classpath/ZipAndJarFileLookupFactoryTest.scala
index db14ff3b1fb4..0dfdb676c26c 100644
--- a/compiler/test/dotty/tools/dotc/classpath/ZipAndJarFileLookupFactoryTest.scala
+++ b/compiler/test/dotty/tools/dotc/classpath/ZipAndJarFileLookupFactoryTest.scala
@@ -6,6 +6,7 @@ import org.junit.Test
 import java.nio.file._
 import java.nio.file.attribute.FileTime
 
+import dotty.tools.dotc.GlobalCache
 import dotty.tools.dotc.core.Contexts.{Context, ContextBase, ctx}
 import dotty.tools.io.AbstractFile
 
@@ -18,7 +19,9 @@ class ZipAndJarFileLookupFactoryTest {
     val f = Files.createTempFile("test-", ".jar")
     Files.delete(f)
 
-    given Context = new ContextBase().initialCtx
+    val freshContext = new ContextBase().initialCtx.fresh
+    freshContext.setGlobalCache(GlobalCache())
+    given Context = freshContext
     assert(!ctx.settings.YdisableFlatCpCaching.value) // we're testing with our JAR metadata caching enabled.
 
     def createCp = ZipAndJarClassPathFactory.create(AbstractFile.getFile(f))
diff --git a/sbt-bridge/src/dotty/tools/xsbt/CompilerBridge.java b/sbt-bridge/src/dotty/tools/xsbt/CompilerBridge.java
index 6e2095a9df1e..3608e5da6336 100644
--- a/sbt-bridge/src/dotty/tools/xsbt/CompilerBridge.java
+++ b/sbt-bridge/src/dotty/tools/xsbt/CompilerBridge.java
@@ -5,6 +5,8 @@
 
 package dotty.tools.xsbt;
 
+import dotty.tools.dotc.GlobalCache;
+
 import xsbti.AnalysisCallback;
 import xsbti.Logger;
 import xsbti.Reporter;
@@ -15,10 +17,12 @@
 import xsbti.compile.Output;
 
 public final class CompilerBridge implements CompilerInterface2 {
+  private final GlobalCache globalCache = GlobalCache.apply();
+
   @Override
   public void run(VirtualFile[] sources, DependencyChanges changes, String[] options, Output output,
     AnalysisCallback callback, Reporter delegate, CompileProgress progress, Logger log) {
-    CompilerBridgeDriver driver = new CompilerBridgeDriver(options, output);
+    CompilerBridgeDriver driver = new CompilerBridgeDriver(options, output, globalCache);
     driver.run(sources, callback, log, delegate, progress);
   }
 }
diff --git a/sbt-bridge/src/dotty/tools/xsbt/CompilerBridgeDriver.java b/sbt-bridge/src/dotty/tools/xsbt/CompilerBridgeDriver.java
index fbbe68235d13..9cfd1a7018f7 100644
--- a/sbt-bridge/src/dotty/tools/xsbt/CompilerBridgeDriver.java
+++ b/sbt-bridge/src/dotty/tools/xsbt/CompilerBridgeDriver.java
@@ -7,6 +7,7 @@
 
 import dotty.tools.dotc.Compiler;
 import dotty.tools.dotc.Driver;
+import dotty.tools.dotc.GlobalCache;
 import dotty.tools.dotc.ScalacCommand;
 import dotty.tools.dotc.config.Properties;
 import dotty.tools.dotc.core.Contexts;
@@ -35,8 +36,9 @@
 public class CompilerBridgeDriver extends Driver {
   private final String[] scalacOptions;
   private final String[] args;
+  private final GlobalCache globalCache;
 
-  public CompilerBridgeDriver(String[] scalacOptions, Output output) {
+  public CompilerBridgeDriver(String[] scalacOptions, Output output, GlobalCache globalCache) {
     super();
     this.scalacOptions = scalacOptions;
 
@@ -47,6 +49,12 @@ public CompilerBridgeDriver(String[] scalacOptions, Output output) {
     System.arraycopy(scalacOptions, 0, args, 0, scalacOptions.length);
     args[scalacOptions.length] = "-d";
     args[scalacOptions.length + 1] = output.getSingleOutputAsPath().get().toAbsolutePath().toString();
+
+    this.globalCache = globalCache;
+  }
+
+  public CompilerBridgeDriver(String[] scalacOptions, Output output) {
+    this(scalacOptions, output, GlobalCache.apply());
   }
 
   private static final String StopInfoError =
@@ -61,6 +69,11 @@ public boolean sourcesRequired() {
     return false;
   }
 
+  @Override
+  public GlobalCache globalCache() {
+    return this.globalCache;
+  }
+
   private static VirtualFile asVirtualFile(SourceFile sourceFile, DelegatingReporter reporter,
       HashMap<AbstractFile, VirtualFile> lookup) {
     return lookup.computeIfAbsent(sourceFile.file(), path -> {