diff --git a/setup.py b/setup.py
index 3a443f95a..a90596d3d 100755
--- a/setup.py
+++ b/setup.py
@@ -217,7 +217,8 @@ def append_nvcc_threads(nvcc_extra_args):
             "nvcc": [
                 "-O3",
                 "-std=c++17",
-                f"--offload-arch={os.getenv('HIP_ARCHITECTURES', 'native')}",
+                # Support multiple architectures via semicolon-separated HIP_ARCHITECTURES
+                *[f'--offload-arch={arch}' for arch in os.getenv('HIP_ARCHITECTURES', 'native').split(';')],
                 "-U__CUDA_NO_HALF_OPERATORS__",
                 "-U__CUDA_NO_HALF_CONVERSIONS__",
                 "-fgpu-flush-denormals-to-zero",