Skip to content

Adding lfcshrink and passing of downstream args to pbDS#150

Closed
plger wants to merge 5 commits into
mainfrom
lfcshrink
Closed

Adding lfcshrink and passing of downstream args to pbDS#150
plger wants to merge 5 commits into
mainfrom
lfcshrink

Conversation

@plger

@plger plger commented Jun 3, 2026

Copy link
Copy Markdown
Collaborator

This is related to #53 :

  • it adds ... arguments to pbDS that are passed to downstream DESeq2::DESeq or edgeR::glmQLFit
  • it adds a shrinkLFC argument to use DESeq2 logFC shrinkage (requires apeglm). edgeR::predFC wasn't included in the end because this isn't different from what the fitting method does, and just offers the option of changing the pseudocount downstream of the fit. This can now anyway be done because ... exposes the pseudocount argument.

Additionally, the default edgeR normalization was changed to TMMwsp.

@plger plger requested a review from HelenaLC June 3, 2026 12:04
@HelenaLC

HelenaLC commented Jun 4, 2026

Copy link
Copy Markdown
Owner

super-seeded by #151

@HelenaLC HelenaLC closed this Jun 4, 2026
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment

Labels

None yet

Projects

None yet

Development

Successfully merging this pull request may close these issues.

3 participants