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ULM Threshold Analysis

This repository contains code and scripts used for analyzing the effect of detection thresholds—specifically false positives and false negatives—on Super-Resolution Ultrasound (SR-US) and Ultrasound Localization Microscopy (ULM) image quality.

The focus of this work is to quantitatively study how microbubble detection errors propagate into super-resolution density maps and affect commonly used image quality metrics.


📦 Data Availability

The datasets used are from UltraSR challenge and can be downloaded from Zenodo:

🔗 https://zenodo.org/records/7271766

Please download the data separately and place it in the appropriate directory structure as expected by the scripts in this repository.


📊 What This Repository Includes

  • Scripts for modifying microbubble detection outputs by:
    • Adding controlled numbers of false positives
    • Introducing false negatives at specified rates
  • Generation of super-resolution density maps
  • Quantitative evaluation using image quality metrics such as:
    • Structural Similarity Index (SSIM)
    • Dice coefficient
    • Peak Signal-to-Noise Ratio (PSNR)
  • Analysis of dense vs. sparse regions in SR maps

The code is intended for research and reproducibility purposes and may require adaptation for different datasets or experimental setups.


📚 Citation

If you use this code or data in your work, please cite the following paper for now:

ArXiv preprint
https://arxiv.org/abs/2411.07426

⚠️ Note:
This work has been accepted to SPIE Medical Imaging 2026.
The citation information will be updated once the final published version becomes available.


📬 Contact

For questions, issues, or collaboration inquiries, please open an issue on GitHub or contact the authors directly.


📄 License

This repository is intended for academic and research use.
Please check the Zenodo record for data-specific licensing information.


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Code for the paper: Evaluating Detection Thresholds: The Impact of False Positives and Negatives on Super-Resolution Ultrasound Localization Microscopy

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