Mathbiomed/SeizureSANC
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Matlab codes for a mathematical model for circadian and vigilance state regulation of seizure-induced sinoatrial nodal cell firing patterns This model was developed using the Li and Kim model 2024 as the baseline, as described in: Pan Li, Sangbo Lee, Kwang-Yeon Choi, Jonathan E. Rubin, and Jae Kyoung Kim, Cardiogenic and Chronobiological Mechanisms in Seizure-Induced Sinus Arrhythmias, 2025 To use the model: SingleRun_ZT_Epilepsy.m to simulate seizure-induced SANC pacemaking activities at a given Zeitgeber time (ZT) with 9 different Si-Pp pairing values ParaSpace_Epilepsy_Ictal.m to calculate the ictal parameter space map at a given ZT ParaSpace_Epilepsy_Postictal.m to calculate the postictal parameter space map at a given ZT -------------------------------------------- Matlab codes for a mathematical model for the circadian regulation of sinoatrial nodal cell pacemaking function This model was developed using the Morotti et al. model 2022 as the baseline, as described in: Pan Li and Jae Kyoung Kim, Circadian regulation of sinoatrial nodal cell pacemaking function: dissecting the roles of autonomic control, body temperature, and local circadian rhythmicity, PLOS Computational Biology, 2024 To use the model: SingleRun_ZT.m to simulate SANC pacemaking at a given ZT PerformanceAmplitude_ZTloop.m to calculate circadian (24h) amplitude and performance of SANC pacemaking Paraspace.m to calculate the Ca oscillator and membrane oscillator parameter space map at a given ZT mouse_SAM_eccODEfile.m ODE file for adult mice mouse_SAM_eccODEfile_aging.m ODE file for aged mice -------------------------------------------- Matlab code of the Morotti et al. model of the sinoatrial node myocyte in mouse updated to investigate the role of the Dnajb6 gene in sick sinus syndrome The Morotti et al. model (https://github.com/drgrandilab/Ding-et-al-2022-mouse-sinoatrial-model) was originally developed by modifying the Kharche et al. model (Am. J. Physiol. Heart Circ. Physiol. 2011, 301, H945–H963) to reproduce an experimental dataset collected in the Proenza Lab. Please cite the following papers when using the Morotti et al. code: Morotti S, Ni H, Peters CH, Rickert C, Asgari-Targhi A, Sato D, Glukhov AV, Proenza C, Grandi E. Intracellular Na+ Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An In Silico Analysis. Int J Mol Sci. 2021 May 26;22(11):5645. doi: 10.3390/ijms22115645. Ding Y, Lang D, Yan J, Bu H, Li H, Jiao K, Yang J, Ni H, Morotti S, Le T, Clark KJ, Port J, Ekker SC, Cao H, Zhang Y, Wang J, Grandi E, Li Z, Shi Y, Li Y, Glukhov AV, Xu X. A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. Elife. 2022 Oct 18;11:e77327. doi: 10.7554/eLife.77327. License: MIT License.