cran-comments.md

colocboost 1.0.10 release comments

This is a CRAN-requested patch update to colocboost 1.0.10.

This patch includes:

• Fixed the CRAN-reported MKL test issue in the CoS robustness tests. The tests now use a stronger simulation setting and aligned inputs for get_robust_ucos() and get_ucos_evidence(), so they no longer depend on weak or platform-sensitive simulated signals.

• R source code changes were limited to targeted computational optimizations and robustness fixes. No package dependencies were changed.

Advanced documentation and tutorials

• Added conceptual and advanced-scenario vignettes to help users understand multi-trait colocalization events and interpret CoS, VCP, and NPC.
• Added practical illustrations of multiple causal variants and weaker disease GWAS signals, together with supporting figures and guidance.

R CMD check results

There is one NOTE about installed package size:

• checking installed package size ... NOTE installed size is 7.1Mb sub-directories of 1Mb or more: data 2.0Mb doc 4.1Mb

This NOTE is expected. The increase from the previous release is primarily due to two substantive documentation vignettes that introduce the conceptual framework for multi-trait colocalization and provide tutorials on advanced analysis scenarios in ColocBoost. These vignettes include six high-level summary figures: three explain the key conceptual definitions and their relationships to existing methods, and three provide empirical illustrations based on representative simulation results. The figures are embedded in the rendered, self-contained vignettes in the doc directory to help users understand the methodology and interpret ColocBoost results. The data directory contains reduced example datasets used in reproducible tutorials. No external data are downloaded during examples or vignette rendering.