Skip to content
View asheorann's full-sized avatar

Highlights

  • Pro

Block or report asheorann

Block user

Prevent this user from interacting with your repositories and sending you notifications. Learn more about blocking users.

You must be logged in to block users.

Maximum 250 characters. Please don’t include any personal information such as legal names or email addresses. Markdown is supported. This note will only be visible to you.
Report abuse

Contact GitHub support about this user’s behavior. Learn more about reporting abuse.

Report abuse
asheorann/README.md

Anushka Sheoran

MSE Computer Science @ Penn  ·  asheoran@seas.upenn.edu  ·  LinkedIn  ·  Personal Website


I'm drawn to problems with real constraints: enterprise systems that have to scale, research questions that need tooling before they can be answered, agents that have to be trustworthy not just capable. Background in bioinformatics. I run CBC, Penn's 900-member community for students building with AI.


Thinking about AI safety

There's a spectrum from intrinsic safety (model weights, training) to extrinsic safety (environment constraints, scaffolding, governance) and most practical work lives in the middle without a clear theory of why. I want to understand what good technical solutions look like at each layer, beyond system prompt interventions.

  • Safety interventions for clinical agents — layered evaluation harness testing whether structured inference-time interventions close the performance gap between frontier and domain-specific medical models, no fine-tuning
  • SWE-bench agent evaluation — baseline + intervention experiments on Claude 3.5 Sonnet; found interventions can shift failure distributions even when top-line resolve rate holds steady

Healthcare + bioinfo tools

  • Agentic pipelines for pharma drug launch readiness — built at Clariem for senior exec teams; trust and auditability mattered as much as capability
  • Single-cell RNA tooling — exploring where agentic workflows can accelerate the manual reasoning steps in scRNA-seq interpretation

Other things I've built

  • Google Search, 1998 (available upon request) — full search engine from scratch: distributed crawler, TF-IDF indexer, PageRank, and search server on AWS EC2
  • Image2GPS — predicts GPS coordinates from campus images using a ConvNeXt + k-NN hybrid; cut baseline localization error by ~70%
  • Market forecasting tool — deterministic, reproducible market forecasts for consulting teams through a 5-stage gated process
  • CBC demos — tooling and demos built for Penn's AI builder community

Research

Pinned Loading

  1. ecDNA_filter_map ecDNA_filter_map Public

    Jupyter Notebook

  2. scPyDR scPyDR Public

    Forked from isabelwang30/scPyDR

    Single-Cell Python Dimensionality Reduction Project from BENG 185

    Python

  3. Bioinformatics_Lab_Materials Bioinformatics_Lab_Materials Public

    This repository contains materials describing implementations of key bioinformatics pipelines

    Jupyter Notebook

  4. scRNA-sequencing_spatial-transcriptomics_paper scRNA-sequencing_spatial-transcriptomics_paper Public

    Forked from JungTzen/beng183_final_paper

  5. bioinformatics_algorithms bioinformatics_algorithms Public

    all code surrounding fundamental bioinformatics algorithms

    Python