Public-data program on the endocannabinoid system and cannabis-related questions in autosomal dominant polycystic kidney disease. No wet lab.
This git tree is the program. Each confirmatory question is its own seal.
| Study | Question (one line) | Status |
|---|---|---|
| 1 — Atlas kill (this directory’s root SEAL files) | Frozen CNR1 in ADPKD PT (GSE185948) + DKD specificity (GSE195460) | GIT-SEALED; OSF; Decide 2026-09-01: C fail |
| 2 — Safety map | studies/cannabis-safety/ — plant vs CBD vs synthetics vs CB1 drugs; Jynarque / Epidiolex |
GIT-SEALED; OSF; v1 map complete (Decide 2026-08-31) |
| 3 — Chemistry | Docking / ADMET | Parked in EXPLORE.md. Study 1 Decide (C fail) does not license docking. |
| Read first | What it is |
|---|---|
QUESTION.md |
Study 1 one sentence |
KILL.md |
Named confounds + pass/fail (study 1) |
CLAIMS.md |
What study 1 may / may not say |
PROTOCOL.md |
Study 1 confirmatory fields (git-sealed; OSF) |
STATUS.md |
You are here (study 1) |
docs/briefing/cannabinoid-adpkd-pathways.md |
Source briefing (not a protocol) |
docs/SUPERPOWERS.md |
How Science Superpowers maps onto SEAL |
EXPLORE.md |
Parked work including study 3 |
Protocol seal (study 1): GIT-SEALED 2026-08-30 (db44b30). OSF: https://osf.io/7g3tn/ . Decide: Gate C fail (2026-09-01). Stop this ADPKD accession; do not dock.
Study text is CC BY 4.0. Third-party datasets stay under their original licenses.
Python 3.12 and uv:
uv syncThe scrna extra (scanpy) is for after study 1 Seal. Unit 00 is the first runner.
Process kernel: .seal/E2E_FLOW.md. This folder is study 1: E2E_FLOW.md.
Explore → Question → Kill → Protocol → Clarify → Analyze → Seal (OSF) → Unit → Run → Converge → Decide → Archive.
Science Superpowers skills fire inside those stages (docs/SUPERPOWERS.md). After Seal, say Unit then Run. Do not say Run on outcomes before Seal. Do not use study 1 CNR1 results to write study 2 claims, or the reverse.