NPC Simulations Utility Files and Datasets

User's Manual

A detailed User's Manual in PDF format is available in this folder.

scripts/

Utility scripts used for initiating and analyzing the simulation. See tutorial for details on how and when to use key scripts.

tutorials/

Tutorial in Jupyter Notebook format for running a basic simulation in a simplified setting + basic analysis

test/

Test script for running a basic simulation in a simplified setting + basic analysis

data/cryoET/

In situ cryo-electron tomography (cryoET) map of the NPC's central channel used for validation of simulated NPC morphology

models/NPC2018/

Kim et al. 2018 model of the NPC scaffold used in this work (see also User's manual)

Reference

Raveh B*, Eliasian R, Rashkovits S, Russel D, Hayama R, Sparks SE, Singh D, Lim R, Villa E, Rout MP*, Cowburn D*, Sali A*. Integrative mapping reveals molecular features underlying the mechanism of nucleocytoplasmic transport. Proc Nat Acad Sci (2025), in press.

License

See LICENSE file.