Baseline and Longitudinal Resting-State fMRI Functional Connectivity in Frontotemporal Dementia

This repository contains analysis scripts, summary-level outputs, and manuscript figures supporting the study:

Baseline Resting-State fMRI Functional Connectivity Fingerprints Outweigh Short-Interval Longitudinal Change in Frontotemporal Dementia

Overview

This study examines baseline and longitudinal resting-state functional connectivity patterns across behavioural variant frontotemporal dementia, non-fluent/agrammatic primary progressive aphasia, semantic variant primary progressive aphasia, and healthy controls using repeated-visit NIFD/FTLDNI data.

The analysis compares baseline subtype-specific functional connectivity fingerprints with longitudinal subtype-by-time functional connectivity slope differences.

Data availability

Raw imaging and clinical data are from the NIFD/FTLDNI cohort and are available through the LONI Image and Data Archive under the appropriate data-use agreements.

Controlled-access raw data, clinical spreadsheets, subject-level imaging derivatives, and identifiable participant-level files are not redistributed in this repository.

Repository structure

• scripts/: analysis and figure-generation scripts
• config/: configuration files
• outputs/tables/: summary-level result tables
• outputs/figures/: manuscript and supplementary figures
• docs/: documentation
• manuscript/: manuscript-related non-sensitive files

Reproducibility note

Because NIFD/FTLDNI data are controlled-access, the full analysis cannot be rerun from this repository alone. Researchers with approved access to the source dataset can adapt these scripts to reproduce the workflow locally.

Citation

If using this repository, please cite the associated manuscript.