mingzapingin / trem2-amyloid-snRNA-seq Star 0 Code Issues Pull requests Subtype-resolved snRNA-seq analysis of TREM2–amyloid interactions in 5XFAD Alzheimer's mouse model. R/Seurat v5 pipeline: QC, Allen Brain Atlas label transfer (25 subtypes), pseudobulk DESeq2, cross-comparison gene classification (Cat1–6), multi-database ORA/GSEA, and partition analysis. bioinformatics deseq2 single-cell alzheimers-disease gsea 5xfad seurat trem2 snrna-seq Updated May 7, 2026 R