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AttentionAML: An Attention-based Deep Learning Framework for Accurate Molecular Diagnosis and Prognosis of Acute Myeloid Leukemia

AttentionAML (an Attention-Based Deep Learning Framework for Identifying Acute Myeloid Leukemia Subtypes), an accurate and effective model for AML subtype identification.

Flowchart of AttentionAML

Flowchart of AttentionAML

Installation

  1. Clone the AttentionAML git repository
git clone https://github.com/wan-mlab/AttentionAML.git
  1. Navigate to the directory of AttentionAML package
cd /your path/AttentionAML
pip install .

Tutorial

Jupyter notebook

  1. Modify the System Path and import module
import sys; sys.path.append('AttentionAML')
from AttentionAML import AttentionAML
  1. unzip and read the test file
test = pd.read_csv('TPM_test.csv', index_col=0)
  1. AML subtype prediction
AttentionAML.Predict(Exp = test, exp_type = 'TPM')
  1. AML risk prediction
risk_efs  = AttentionAML.PredictRisk(Exp = test, exp_type = 'TPM', endpoint = 'efs')
risk_os   = AttentionAML.PredictRisk(Exp = test, exp_type = 'TPM', endpoint = 'os')
  1. Example Outputs

Example Outputs

The prediction results will be stored and exported to the Prediction_results.csv

Authors

Lusheng Li, Shibiao Wan

Publication

AttentionAML: An Attention-based Deep Learning Framework for Accurate Molecular Categorization of Acute Myeloid Leukemia Lusheng Li, Joseph D. Khoury, Jieqiong Wang, Shibiao Wan bioRxiv 2025.05.20.655179v1; doi: https://doi.org/10.1101/2025.05.20.655179

License

License: GPL v3

GNU GENERAL PUBLIC LICENSE
Version 3, 29 June 2007

This program is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, either version 3 of the License, or (at your option) any later version.

This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details.

You should have received a copy of the GNU General Public License along with this program. If not, see https://www.gnu.org/licenses/.

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AttentionAML: an Attention-based MLP Model for Identifying Acute Myeloid Leukemia Subtypes

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