Releases: AWGL/variant_classification_DB
Release list
1.6.1
1.6.0
New release for Genome Build 38.
All unit tests pass.
Tested and Reviewed
1.5.0
Fix issue #40. Allow more than one PV code. Note this doesn't allow more than one PV code in isolation. Need to decide what this should come out as.
Add download variant list function. Allows users to download a list of variants and set each classification category to be assigned to a white or black list. To be used in upcoming variant database software.
Add POST API for adding variants. Variants can be added via a request. Users must authenticate to get a token before doing this. Again to be used by new variant database.
Remove Mutalyzer requirement. Incorrect variants are caught by VEP.
Upgrade to Django 2.2
Style changes. Remove relative imports where possible.
1.4.0
- Updated VEP cache to v100
- Added setting to settings file to switch between local and cluster config for static and media files
- Added configs for the admin page, so it shows more information and has a search box
- Added django-debug-toolbar https://django-debug-toolbar.readthedocs.io/en/latest/index.html - can be used to see why loading the variants tab is slow
- Added digenic dominant and digenic recessive to inheritence patterns
- Added option to apply PS2, PM3 and PM6 at very strong, BS1 at standalone
- Optimise queries for classifications and variants page to speed up database
- Fix issue when changing transcript
1.3.0
1.2.2
we are now using acgs 2020v4 guidelines.
1.2.0
-
Change guidelines to take into account 2019 changes:
PVS1+PM = pathogenic instead of likely pathogenic
2xPS = likely pathogenic instead of pathogenic (3xPS will still be pathogenic) -
Add hemizygous and mosaic to genotype options
-
Change pending button to light grey
Small update introducing a few new features
- Genotype now imported from TSV.
- Users can now delete comments before finalisation.
- Users can send classifications back for first check.
Changes to User display
- New table showing selected ACMG codes.
- More text allowed in affected with box.
- Screenshots (.png) now display as thumbnail.
- Previous inheritance patterns for gene now remembered between analysis.