hsv-1

This project focuses on the development of dormant nanoparticles that activate in response to specific biochemical signals, such as those associated with the reactivation of HSV-1 or the presence of disease markers in cancer. These nanoparticles deliver targeted therapies to neutralize viruses or target diseased cells before symptoms appear.

Conservation-constrained, escape-aware CRISPR guide design for HSV-1. Finds that the sampling resolution of the public genome corpus, not repair biology, limits how low an escape probability can be demonstrated.